Origins of central mucoepidermoid carcinoma: systematic review
DOI:
https://doi.org/10.11606/issn.1679-9836.v100i1p41-48Keywords:
Carcinoma, Etiology, Salivary glands, submandibular glandAbstract
Mucoepidermoid carcinoma is a malignant tumor usually associated with salivary glands. Only 2-4% of all mucoepidermoid carcinomas have a primary intraosseous site (central mucoepidermoid carcinoma), which the etiogenesis remaining obscure, justifying the importance of researching the subject. Objective: Discover the most probable etiology (or etiologies) of intraosseous mucoepidermoid carcinoma. Method: systematic review according to the recommendations of PRISMA (Preferred Reporting items for Systematics Review and Meta-analysis Statement). The search bases consulted were: PubMed, Portal CAPES and Google academic, and after the inclusion and exclusion criteria, seven articles were selected to answer the research objective, for which the Newcastle-Ottawa tool was applied for risk analysis of bias and methodological quality. The search, selection, extraction and risk of bias were carried out by three independent researchers. Results: There are two main etiological hypotheses of intraosseous mucoepidermoid carcinoma: (1) derived from an odontogenic cyst and (2) derived from ectopic remains. Conclusions: As the evidence indicates, the pluripotent potential of cells contained in odontogenic cysts would be responsible for metaplasia and subsequent carcinogenesis. In cases derived from ectopic remains, the association with t (11; 19) translocation and the CTRC1-MAML2 fusion transcript as an etiological or early event is clear.
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Copyright (c) 2021 Khalil Abdo Kansou, Mozarth Matheus Silvino do Nascimento, Elaine Rossi Ribeiro
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