The measurement of biomarkers in the diagnosis and prognosis of neonatal sepsis: a review of the literature
DOI:
https://doi.org/10.11606/issn.1679-9836.v100i5p494-502Keywords:
Neonatal sepsis, Biomarkers, NewbornAbstract
Introduction: Neonatal sepsis (NS) is an important cause of morbidity and mortality in newborns despite advances. Possessing a complex pathophysiology, NS presents different clinical forms and eventually scarce guiding symptoms or signs; which makes diagnosis, severity analysis and timely therapy difficult. Objective: To analyze the use of biomarkers for the early diagnosis and prognostic evaluation of SN. Method: Literature review with search in PubMed/MEDLINE, Scielo and VHL databases, conducted between February and March 2021, with analysis of 21 articles published from January 2010 to December 2020. Results and Discussion: The biomarkers used in SN analysis, such as C-reactive protein (CRP), procalcitonin (PCT), interleukins (IL-6, IL-8), tumor necrosis factor alpha (TNF-α) and cell surface markers, are important for faster diagnosis and assistance, enabling better prognosis for neonatal cases. Conclusion: The study of biomarkers with the knowledge about the modification of their serum levels during disease progression can facilitate the analysis and predict the severity of SN, besides guiding the establishment of an early protocol, increasing the proportion of patients who receive an effective treatment and obtain better prognoses.
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Cortés JS, Cruz LXF, Zúñiga EB, Narváez CF, Fonseca-Becerra CE. Sepsis neonatal: aspectos fisiopatológicos y biomarcadores. Médicas UIS. 2019;32(3):35-47. doi: https://doi.org/10.18273/revmed.v32n3-2019005
Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):762–74. doi: 10.1001/jama.2016.0288
Kissoon N, Carcillo JA, Espinosa V, Argent A, Devictor D, Madden M, et al. World Federation of Pediatric Intensive Care and Critical Care Societies: Global Sepsis Initiative. Pediatr Crit Care Med. 2011;12(5):494–503. doi: 10.1097/PCC.0b013e318207096c
Andrés Ledesma C, Calvo Nieves MD, Andaluz-Ojeda D. El paradigma de la sepsis: en busca del biomarcador perfecto. Rev Electrónica Dr. Zoilo E. Marinello Vidaurreta. 2018;11(2):61-3. Disponível em: http://revzoilomarinello.sld.cu/index.php/zmv/article/view/1930
Wright JK, Hayford K, Tran V, Al Kibria GM, Baqui A, Manajjir A, Et Al. Biomarkers of endothelial dysfunction predict sepsis mortality in young infants: a Matched Case-Control Study. BMC Pediatr. 2018;18(1):118. doi https://doi.org/10.1186/s12887-018-1087-x
Pierrakos C, Vincent J-L. Sepsis biomarkers: a review. Crit Care. 2010;14(1):R15. doi: https://doi.org/10.1186/cc8872
Bustos B R, Padilla P O. Valor predictivo de la procalcitonina en niños con sospecha de sepsis. Rev Chil Pediatría. 2015;86(5):331–6. doi: https://doi.org/10.1016/j.rchipe.2015.07.006
Siahanidou T, Margeli A, Tsirogianni C, Charoni S, Giannaki M, Vavourakis E, et al. Clinical value of plasma soluble urokinase-type plasminogen activator receptor levels in term neonates with infection or sepsis: a prospective study. Mediators Inflamm. 2014;2014:375702. doi: 10.1155/2014/375702.
González-Rangel D, Camacho-Moreno G, Quintero-Guevara O. Procalcitonin as a biomarker for sepsis in children. Rev Fac Med. 2016;64(2):215-21. doi: https://doi.org/10.15446/revfacmed.v64n2.50585
Karsas M, Becker PJ, Green RJ. Serious bacterial infections in febrile young children: lack of value of biomarkers. South Afr J Child Health. 2016;10(1):33–6. doi: 10.7196/SAJCH.2016.v10i1.980
Bustos B R, Araneda C H. Procalcitonina para el diagnóstico de la sepsis tardía en recién nacidos de muy bajo peso de nacimiento. Rev Chil Infectol. 2012;29(5):511–6. doi: http://dx.doi.org/10.4067/S0716-10182012000600005
Mickiewicz B, Thompson GC, Blackwood J, Jenne CN, Winston BW, Vogel HJ, et al. Biomarker phenotype for early diagnosis and triage of sepsis to the Pediatric Intensive Care Unit. Sci Rep. 2018;8(1):16606. doi: 10.1038/s41598-018-35000-7.
Reis Machado J, Soave DF, Silva MV, Menezes LB, Etchebehere RM, Monteiro MLGR, et al. Neonatal sepsis and inflammatory mediators. Mediators Inflamm. 2014;2014:269681. doi: 10.1155/2014/269681.
Lanziotti VS, Póvoa P, Soares M, Silva JRL, Barbosa AP, Salluh JIF. Use of biomarkers in pediatric sepsis: literature review. Rev Bras Ter Intens. 2016;28(4):472–82. doi: https://doi.org/10.5935/0103-507X.20160080
Carcillo JA, Sward K, Halstead ES, Telford R, Jimenez-Bacardi A, Shakoory B, et al. A systemic inflammation mortality risk assessment contingency table for severe sepsis. Pediatr Crit Care Med. 2017;18(2):143–50. doi: 10.1097 / PCC.0000000000001029
Yoon SH, Kim EH, Kim HY, Ahn JG. Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis. BMC Infect Dis. 2019;19(1):760. doi: https://doi.org/10.1186/s12879-019-4397-1
Prashant A, Vishwanath P, Kulkarni P, Sathya Narayana P, Gowdara V, Nataraj SM, et al. Comparative assessment of cytokines and other inflammatory markers for the early diagnosis of neonatal sepsis–a case control study. PLoS ONE. 2013;8(7).e68426. doi: 10.1371/journal.pone.0068426.
Cisneros BG, Benítez PJC. Identificación de los factores de bajo riesgo en el lactante pequeño con fiebre sin foco evidente. Acta Méd Grupo Ángeles. 2018;16(3):219–25. Disponível em: http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1870-72032018000300219&lng=es.
Decembrino L, De Amici M, Pozzi M, De Silvestri A, Stronati M. Serum calprotectin: a potential biomarker for neonatal sepsis. J Immunol Res. 2015;2015:147973. doi: https://doi.org/10.1155/2015/147973
Alqahtani MF, Smith CM, Weiss SL, Dawson S, Ranaivo HR, Wainwright MS. Evaluation of new diagnostic biomarkers in pediatric sepsis: matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, mid-regional pro-atrial natriuretic peptide, and adipocyte fatty-acid binding protein. PLOS ONE. 2016;11(4):e0153645. doi: https://doi.org/10.1371/journal.pone.0153645
Wang J, Wang Z, Zhang M, Lou Z, Deng J, Li Q. Diagnostic value of mean platelet volume for neonatal sepsis: A systematic review and meta-analysis. Medicine (Baltimore). 2020;99(32):e21649. doi: 10.1097 / MD.0000000000021649
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Copyright (c) 2021 Yngrid Carneiro de Aguiar, Pedro Henrique Bersan Menezes, Sarah Godoi de Carvalho, Danielle Braz Amarílio da Cunha, Beatriz Moraes Gonçalves, Juliana Barrozo Fernandes Borges , Camila Nakamura Perissê Pereira , Júlia Pinheiro São Pedro, Flávia Alves Neves Mascarenhas
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