Negative impacts of the administration of hydroxycloroquine and anticoagulant in patients with SARS-COV-2 infection: a randomized clinical trial

Authors

DOI:

https://doi.org/10.11606/issn.1679-9836.v101i4e-187545

Keywords:

COVID-19, SARS-CoV-2, Prevention, Complications

Abstract

Purpose: To evaluate antimalarial with or without anticoagulant treatment, in patients with recent SARS-COV-2 infection. Methods: Clinical study carried out at Samuel Libânio Clinic Hospital, University of Vale do Sapucaí, Pouso Alegre-MG. Approved by the Ethics Committee (4.034.077) and registered in the Clinical Trials (NCT04788355). Suspected patients for COVID-19 were included in the emergency room. The groups were: C (control) with 6 patients, A (anticoagulant apixaban) with 9 patients, H (hydroxychloroquine) with 5 patients and HA (hydroxychloroquine and anticoagulant apixaban) with 8 patients. Results: there were no significant differences between groups. The HA group, in which there was an intervention with two drugs, presented a greater number of days with symptoms (p = 0.037) and worse results, when compared to the control: most relevant symptoms, were: cough (p = 0.001), and anosmia / ageusia (p = 0.011) headache (p = 0.001). Conclusion: The present study began when there were doubts about the use of drugs such as Hydroxychloroquine (HCQ) and apixaban (APX). The reduced “n” was defined through bureaucratic and polemic issues independent of the authors’ actions. No clinical benefit was associated with HCQ and APX. There was an increase in the number of symptomatic days when HCQ and APX were administered. Despite the limitations, there was no therapeutic indication of the evaluated drugs.

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Author Biographies

  • Matheus Henrique Fernandes, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Matheus Rodrigues de Oliveira, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Alfredo Herbert Zielke Filho, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Clóvis José Torres Gomes, Universidade do Vale do Sapucaí

    Nursing care coordinator, Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • Lucyara Martins Oliveira, Universidade do Vale do Sapucaí

    Nursing care coordinator, Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • Frederico Palumbo Araújo, Universidade do Vale do Sapucaí

    Rheumatologist, Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • Sofia Mirela Schreier Rodrigues, Universidade do Vale do Sapucaí

    Cardiology resident, Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • Karine Paiva de Andrade, Universidade do Vale do Sapucaí

    Cardiology resident, Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • Ana Clara Beraldo Muniz, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Gabriel Prado Leão Teixeira, Faculdade de Medicina de Itajubá

    Graduate student, Medicine, Itajubá Medical School, Itajubá-MG, Brazil.

  • Guilherme Tadeu Tucci Castilho Junior, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Mariana Gazzinelli Maiolini, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Camilla Kallás Hueb, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Elisa Rosa Silva, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Paula Fernanda Correa, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Marcella Nora Maia, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Maria Eugênia Sousa Magalhães, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Laís Boczar Dias, Faculdade de Medicina de Itajubá

    Graduate student, Medicine, Itajubá Medical School, Itajubá-MG, Brazil.

  • Pedro Augusto Schreier Rodrigues, Universidade do Vale do Sapucaí

    Graduate student, Medicine, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • José Renato de Melo, Universidade do Vale do Sapucaí

    PhD, Coordinator of the Intensive Care Unit, Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • Breno César Diniz Pontes, Universidade do Vale do Sapucaí

    MD, Master, Professional Masters in Sciences Applied to Health, Infectologist, Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • Paulo Roberto Maia, Universidade do Vale do Sapucaí

    PhD, Professional Masters in Sciences Applied to Health, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

  • Sérgio Rodrigo Beraldo, Universidade do Vale do Sapucaí

    Professor in the Cardiology Department, Vale do Sapucaí University and Samuel Libânio Clinic Hospital, Pouso Alegre-MG, Brazil.

  • José Dias da Silva Neto, Universidade do Vale do Sapucaí

    PhD, Professional Masters in Sciences Applied to Health, Vale do Sapucaí University, Pouso Alegre-MG, Brazil.

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Published

2022-07-15

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Vol. 101 No. 4 (2022)

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Artigos Originais/Originals Articles

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Copyright (c) 2022 Matheus Henrique Fernandes, Matheus Rodrigues de Oliveira, Alfredo Herbert Zielke Filho, Clóvis José Torres Gomes, Lucyara Martins Oliveira, Frederico Palumbo Araújo, Sofia Mirela Schreier Rodrigues, Karine Paiva de Andrade, Ana Clara Beraldo Muniz, Gabriel Prado Leão Teixeira, Guilherme Tadeu Tucci Castilho Junior, Mariana Gazzinelli Maiolini, Camilla Kallás Hueb, Elisa Rosa Silva, Paula Fernanda Correa, Marcella Nora Maia, Maria Eugênia Sousa Magalhães, Laís Boczar Dias, Pedro Augusto Schreier Rodrigues, José Renato de Melo, Breno César Diniz Pontes, Paulo Roberto Maia, Sérgio Rodrigo Beraldo, José Dias da Silva Neto

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How to Cite

Fernandes, M. H., Oliveira, M. R. de, Zielke Filho, A. H., Gomes, C. J. T., Oliveira, L. M., Araújo, . F. P., Rodrigues, S. M. S., Andrade, . K. P. de, Muniz, . A. C. B. ., Teixeira, . G. P. L. ., Castilho Junior, . G. T. T., Maiolini, . M. G. ., Hueb, C. K., Silva, . E. R., Correa, . P. F., Maia, . M. N., Magalhães, . M. E. S., Dias, . L. B., Rodrigues, . P. A. S. ., … Silva Neto, J. D. da. (2022). Negative impacts of the administration of hydroxycloroquine and anticoagulant in patients with SARS-COV-2 infection: a randomized clinical trial. Revista De Medicina, 101(4), e-187545. https://doi.org/10.11606/issn.1679-9836.v101i4e-187545