Angioedema with haloperidol: a case report
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i2e-191528Keywords:
Haloperidol, Angioedema, Side effectsAbstract
Haloperidol is a first-generation antipsychotic and one of the most commonly used drugs within this category. It is a potent centrally acting antagonist of type 2 dopamine receptors, with low anti-alpha-1-adrenergic activity and no antihistaminic or anticholinergic activity, regularly used in cases of agitation. Angioedema is an especially serious side effect, characterized by marked edema of the subcutaneous or submucosal tissue, and can affect various parts of the body, and may even culminate, in the most severe cases, in death. It has already been described with the administration of several antipsychotics, such as clozapine, risperidone, ziprasidone, and chlorpromazine, but it is rare as a result of administration of haloperidol, occurring in <1% of cases. This article aims to describe the development of angioedema in a patient with acute confusional syndrome after the second administration of IM haloperidol for symptomatic control of agitation in an emergency department setting.
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Tyler MW, Zaldivar-Diez J, Haggarty SJ. Classics in chemical neuroscience: haloperidol. ACS Chem Neurosci. 2017;8(3):444-53. doi: 10.1021/acschemneuro.7b00018
Landry P, Rousseau AM, Skalli L. Adverse effects of antipsychotics. In:Hertzman M, Adler L, editors. Clinical Trials in Psychopharmacology. Wiley; 2010. chap.17, p.337-80. https://doi.org/10.1002/9780470749180.ch17
Haloperidol: drug information. UpToDate. 2019;18:1-40. Available from: https://www.uptodate.com/contents/haloperidol-drug-information/print?search=haloperidol&source=panel_search_result&selectedTitle=1~148&%E2%80%A6
Rai D, Garg RK, Malhotra HS, Verma R, Jain A, Tiwari SC, et al. Acute confusional state/delirium: An etiological and prognostic evaluation. Ann Indian Acad Neurol. 2014;17(1):30-4. doi: 10.4103/0972-2327.128541
Loverde D, Files DC, Krishnaswamy G. Angioedema. Crit Care Med. 2017;45(4):725-35. doi: 10.1097/CCM.0000000000002281
AlMadhyan A. Angioedema associated with haloperidol. Int J Health Sci (Qassim). 2015;9(1):1-3. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394941/
Regateiro FS, Marques ML, Gomes ER. Drug-induced anaphylaxis: an update on epidemiology and risk factors. Int Arch Allergy Immunol. 2020;181(7):481-7. doi: 10.1159/000507445
Muzyk A, Cvelich R, Kincaid B, Preud’homme X. Angioedema occurring in patient prescribed iloperidone and haloperidol: a cross-sensitivity reaction to antipsychotics from different chemical classes. J Neuropsychiatry Clin Neurosci. 2012;24:506-7. https://doi.org/10.1176/appi.neuropsych.11040094
Williams GD. Cross-reaction of angioedema with clozapine, olanzapine, and quetiapine: a case report. Ment Health Clin. 2019;9(5):315-7. doi: 10.9740/mhc.2019.09.315.
Soumya RN, Grover S, Dutt A, Gaur N. Angioneurotic edema with risperidone: a case report and review of the literature. Gen Hosp Psychiatry. 2010;32(6):646.e1-646.e3. doi: 10.1016/j.genhosppsych.2010.03.005
Balai M, Ansari F, Gupta LK, Khare AK, Mittal AK. Urticaria and angioedema associated with haloperidol. Indian J Dermatol. 2017;62(5):539-40. doi: 10.4103/ijd.IJD
Masiran R. Persistent oromandibular dystonia and angioedema secondary to haloperidol. BMJ Case Rep. 2017;1-3. doi: 10.1136/bcr-2017-220817
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Copyright (c) 2022 Ana Lúcia Rodrigues Costa, Sabrina Jesus, Mónica Almeida, João Alcafache
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