A Cross-sectional study on olfactory disorder in COVID-19: characteristics and prognostic factors
DOI:
https://doi.org/10.11606/issn.1679-9836.v101i6e-196957Keywords:
Anosmia, COVID-19, Therapeutics, Olfaction disordersAbstract
Objective: To present the characteristics and prognostic factors of anosmia and hyposmia in patients infected with COVID-19 in a city in Brazil. Methods: A cross-sectional study through telephone contact, a survey was carried out with a pre-established questionnaire in a population of 80 patients. Results: Among the 80 research participants, 66.3% were female. 90% reported anosmia and 10% reported hyposmia. 5% of the interviewees evolved the condition with hospitalization. 5% of patients underwent treatment, which was olfactory therapy. Of these patients, 75% considered olfactory therapy to be an effective treatment. Conclusions: The highest number of olfactory dysfunction was found in the lowest age group and in women, variables associated with a better prognosis. Olfactory loss is related to a milder course of the disease and, consequently, to a lower number of hospitalizations. Evidence points to olfactory therapy as a promising treatment.
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Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel coronavirus from patients with pneumonia in China, 2019. New Engl J Med. 2020;382(8). https://doi.org/10.1056/NEJMoa2001017
Miller MA, Cappuccio FP. A systematic review of COVID-19 and obstructive sleep apnoea. Sleep Med Rev. 2020;101382. https://doi.org/10.1016/j.smrv.2020.101382
Rocke J, Hopkins C, Philpott C, Kumar N. Is loss of sense of smell a diagnostic marker in COVID‐19: a systematic review and meta‐analysis. Clin Otolaryngol. 2020;45(6):914–22. https://doi.org/10.1111/coa.13620
Meng X, Deng Y, Dai Z, Meng Z. COVID-19 and anosmia: A review based on up-to-date knowledge. Am J Otolaryngol. 2020;41(5):102581. https://doi.org/10.1016/j.amjoto.2020.102581
Klopfenstein T, Kadiane-Oussou NJ, Toko L, Royer P-Y, Lepiller Q, Gendrin V, et al. Features of anosmia in COVID-19. Med Mal Infect. 2020;50(5):436–9. https://doi.org/10.1016/j.medmal.2020.04.006
Ottaviano G, Carecchio M, Scarpa B, Marchese-Ragona R. Olfactory and rhinological evaluations in SARS-CoV-2 patients complaining of olfactory loss. Rhinol J. 2020;58(4):400–1. https://doi.org/10.4193/Rhin20.136
Moein ST, Hashemian SM, Mansourafshar B, Khorram-Tousi A, Tabarsi P, Doty RL. Smell dysfunction: a biomarker for COVID-19. Int Forum Allergy Rhinol. 2020;10(8):944–50. https://doi.org/10.1002/alr.22587
Boscutti A, Delvecchio G, Pigoni A, Cereda G, Ciappolino V, Bellani M, et al. Olfactory and gustatory dysfunctions in SARS-CoV-2 infection: A systematic review. Brain Behav Immun Health. 2021;15(100268):100268. https://doi.org/10.1016/j.bbih.2021.100268
Whitcroft KL, Hummel T. Olfactory dysfunction in COVID-19. JAMA. 2020;323(24):2512–4. https://doi.org/10.1001/jama.2020.8391
Soler ZM, Patel ZM, Turner JH, Holbrook EH. A primer on viral-associated olfactory loss in the era of COVID-19. Int Forum Allergy Rhinol. 2020;10(7):814–20. https://doi.org/10.1002/alr.22578
Zou L, Ruan F, Huang M, Liang L, Huang H, Hong Z, et al. SARS-CoV-2 viral load in upper respiratory specimens of infected patients. New Engl J Med. 2020;382(12):1177–9. https://doi.org/10.1056/NEJMc2001737
Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020;277(8):2251–61. https://doi.org/10.1007/s00405-020-05965-1
Avcı H, Karabulut B, Farasoglu A, Boldaz E, Evman M. Relationship between anosmia and hospitalisation in patients with coronavirus disease 2019: an otolaryngological perspective. J Laryngol Otol. 2020;134(8):710–6. https://doi.org/10.1017/S0022215120001851
Bagheri SH, Asghari A, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK, Jalessi M, Mohebbi A, Alizadeh R, Honarmand AA, Ghalehbaghi B, Salimi A, Dehghani Firouzabadi F. Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak in Iran. Med J Islam Repub Iran. 2020;34(1):446-452. https://doi.org/10.34171/mjiri.34.62
Agyeman AA, Lee Chin K, Landersdorfer CB, Liew D, Ofori-Asenso R. Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-analysis. Mayo Clin Proc. 2020;95(8):1621–31. https://doi.org/10.1016/j.mayocp.2020.05.030
Lefèvre N, Corazza F, Valsamis J, Delbaere A, De Maertelaer V, Duchateau J, et al. The number of X chromosomes influences inflammatory cytokine production following Toll-Like receptor stimulation. Front Immunol. 2019;10. https://doi.org/10.3389/fimmu.2019.01052
Levinson R, Elbaz M, Ben-Ami R, Shasha D, Levinson T, Choshen G, et al. Time course of anosmia and dysgeusia in patients with mild SARS-CoV-2 infection. Infect Dis. 2020;52(8):600–2. https://doi.org/10.1080/23744235.2020.1772992
Mutiawati E, Fahriani M, Mamada SS, Fajar JK, Frediansyah A, Maliga HA, et al. Anosmia and dysgeusia in SARS-CoV-2 infection: incidence and effects on COVID-19 severity and mortality, and the possible pathobiology mechanisms - a systematic review and meta-analysis. F1000Research. 2021;10:40. https://doi.org/10.12688/f1000research.28393.1
Talavera B, García-Azorín D, Martínez-Pías E, Trigo J, Hernández-Pérez I, Valle-Peñacoba G, et al. Anosmia is associated with lower in-hospital mortality in COVID-19. J Neurol Sci. 2020;419:117163. https://doi.org/10.1016/j.jns.2020.117163
Foster KJ, Jauregui E, Tajudeen B, Bishehsari F, Mahdavinia M. Smell loss is a prognostic factor for lower severity of coronavirus disease 2019. Ann Allergy Asthma Immunol. 2020;125(4):481–3. https://doi.org/10.1016/j.anai.2020.07.023
Yan CH, Faraji F, Prajapati DP, Ostrander BT, DeConde AS. Self‐reported olfactory loss associates with outpatient clinical course in Covid‐19. Int Forum Allergy Rhinol. 2020;10(7):821–31. https://doi.org/10.1002/alr.22592
Giorli A, Ferretti F, Biagini C, Salerni L, Bindi I, Dasgupta S, et al. A literature systematic review with meta-analysis of symptoms prevalence in Covid-19: the relevance of olfactory symptoms in infection not requiring hospitalization. Curr Treat Options Neurol. 2020;22(10). https://doi.org/10.1007/s11940-020-00641-5
Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS. Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms. Int Forum Allergy Rhinol. 2020;10(7):806–13. https://doi.org/10.1002/alr.22579
Spinato G, Fabbris C, Polesel J, Cazzador D, Borsetto D, Hopkins C, et al. Alterations in smell or taste in mildly symptomatic outpatients with SARS-CoV-2 infection. JAMA. 2020;323(20):2089–90. 10.1001/jama.2020.6771
Qiao X-F, Wang G-P, Li X, Bai Y-H, Zheng W. Analysis of the clinical effect of olfactory training on olfactory dysfunction after upper respiratory tract infection. Acta Otolaryngol. 2019;139(7):643–6. https://doi.org/10.1080/00016489.2019.1614224
Yan XG, Gao X, Sun ZF, Guo YC, Yao LY, Liu J, et al. Efficacy and associated factors of olfactory training in the treatment of olfactory dysfunction. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018;53(11):815–9. https://doi.org/10.3760/cma.j.issn.1673-0860.2018.11.004
Mullol J, Alobid I, Mariño-Sánchez F, Izquierdo-Domínguez A, Marin C, Klimek L, et al. The loss of smell and taste in the COVID-19 outbreak: a tale of many countries. Curr Allergy Asthma Rep. 2020;20(10). https://doi.org/10.1007/s11882-020-00961-1
Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, et al. Position paper on olfactory dysfunction. Rhinol J. 2017;54(26):1–30. https://doi.org/10.4193/Rhino16.248
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