Vancomycin infusion reaction: case report

Abstract

Introduction: The vancomycin infusion reaction, previously known as red man syndrome, is an adverse effect usually observed with the use of vancomycin in rapid intravenous infusion and that manifests itself, in most cases, minutes after administration of the first dose of the therapeutic scheme. However, there are rare situations in which this reaction manifests with slow intravenous infusion. In general, this regresses about 20 minutes after vancomycin is discontinued and treatment is instituted, nevertheless, more rarely, it can last from hours to days. Objectives: This study aims to inform, discuss and analyze the relevance of continuous monitoring and individualization of the dosage of this antibiotic, seeking to prevent the occurrence of adverse effects. Method: Case report of a patient who developed an infusion reaction to vancomycin two days after the end of the therapeutic regimen. Results: The patient reported showed partial regression of the adverse effect after nine days of the development of the condition and the institution of therapeutic measures. Conclusion: Thus, in addition to adjusting the dosage of this drug according to renal function, it is extremely important to be aware of the possibility of this adverse reaction occurring in unusual scenarios in medical practice.