Hyperparathyroidism associated with primary hypercalciuria in a patient with recurrent renal lithiasis

Authors

DOI:

https://doi.org/10.11606/issn.1679-9836.v102i2e-199863

Keywords:

Hypercalciuria, Urinary lithiasis, Secondary hyperparathyroidism

Abstract

Urinary lithiasis affects 5 to 10% of the Brazilian population and has a recurrence rate after the first crisis of up to 50% in five to ten years. Hypercalciuria is the most frequent metabolic alteration found in these patients with renal stones and can be characterized in three ways: (1) absorptive (intestinal), (2) renal and (3) resorptive (bone). OBJECTIVE: To describe the case of a patient with recurrent nephrolithiasis associated with hypercalciuria and discuss the association with secondary hyperparathyroidism. MATERIALS AND METHODS: The information was obtained through a review of the medical records, interviews with the patient, photographic record of the diagnostic methods to which the patient was submitted to and review of the literature. CONCLUSION: Calculus caused by sustained primary hypercalciuria can cause hyperparathyroidism secondary to hypocalcemia, so a differential diagnosis with primary hyperparathyroidism and other causes of secondary hyperparathyroidism is necessary.

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Author Biographies

  • Beatriz D'Andrea Pigosssi, Pontificia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

    Faculdade de Ciências Médicas e da Saúde PUC/SP: Sorocaba, SP, BR

  • Lígia Oliveira Mattos, Pontificia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

    Faculdade de Ciências Médicas e da Saúde PUC/SP: Sorocaba, SP, BR

  • João Carlos Ramos Dias, Pontificia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

    Faculdade de Ciências Médicas e da Saúde PUC/SP: Sorocaba, SP, BR

  • Ronaldo D’Avila, Pontificia Universidade Católica de São Paulo. Faculdade de Ciências Médicas e da Saúde

    Faculdade de Ciências Médicas e da Saúde PUC/SP: Sorocaba, SP, BR

References

Freitas RF, Vieira DR, França DS. Prevenção de Litíase Urinária a Partir de Terapia de Reposição de Citratos de Potássio e Magnésio: relato de caso. Rev Univ Vale Rio Verde. 2017;15(1):49-53. doi: 10.5892/ruvrd.v15i1.3398

Gomes PN, Cabrita M, Rodrigues M, Vega P, Coutinho A, Rosa G, et al. Profilaxia da litiase renal. Acta Urol. 2005;22(3):47-56.

Santos FM dos, Peres AK, Mandotti MR, Peres LAB. Metabolic investigation in patients with nephrolithiasis. Einstein (São Paulo). 2017;15(4):452-6. doi: 10.1590/s1679-45082017ao4029

Peres LAB, de Almeida LP, Bolson LB, Brites M de F, David JM, Tazima L. Investigation of nephrolithiasis in the West of Paraná. J Bras Nefrol. 2011;33(2):160-5. doi: 10.1590/S0101-28002011000200007

Aragão IA, Junior JADR, Conte PHP, Vieir Alves RR, Ribeiro CAF. Principais aspectos da litogênese. 2008;315-28.

Ita D, Heilberg P, Federal U, De S, Escola P, Nestor P, et al. Diretrizes de litíase urinária da Sociedade Brasileira de Nefrologia. J Bras Nefrol. 2002;24(4):203-7.

Damasio PCG, Amaro CRP, Berto SJP, Cunha NB, Pichutte AC, Padovani CR, et al. Urinary lithiasis and idiopathic hypercalciuria: the importance of dietary intake evaluation. Int Braz J Urol. 2010;36(5):557-62. doi: 10.1590/S1677-55382010000500005

Spivacow FR, del Valle EE, Lores E, Rey PG. Kidney stones: Composition, frequency and relation to metabolic diagnosis. Medicina (B Aires). 2016;76(6):343-8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27959841.

Pozdzik A, Maalouf N, Letavernier E, Brocheriou I, Body JJ, Vervaet B, et al. Meeting report of the “Symposium on kidney stones and mineral metabolism: calcium kidney stones in 2017.” J Nephrol. 2019;32(5):681-98. doi: 10.1007/s40620-019-00587-1

Wróblewski T, Wystrychowski A. Hypercalciuria. Przegl Lek. 2011;68(2):107-13.

Guerra A, Folesani G, Nouvenne A, Ticinesi A, Allegri F, Pinelli S, et al. Family history influences clinical course of idiopathic calcium nephrolithiasis: case-control study of a large cohort of Italian patients. J Nephrol. 2016;29(5):645-51. doi: 10.1007/S40620-015-0225-X

Leslie SW, Sajjad H. Hypercalciuria [Internet]. StatPearls. StatPearls Publishing; 2021 [cited 2021 Nov 7]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448183/.

Pak CYC, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, et al. Defining hypercalciuria in nephrolithiasis. Kidney Int. 2011;80(7):777-82. doi: 10.1038/ki.2011.227

Martínez García M, Trincado Aznar P, Pérez Fernández L, Azcona Monreal I, López Alaminos ME, Acha Pérez J, et al. Comparación de los efectos inducidos sobre la calciuria por tiazidas y diferentes dosis de sal en la dieta: implicaciones en la práctica clínica. Nefrología. 2019;39(1):73-9. doi: 10.1016/j.nefro.2018.05.008

Foley KF, Boccuzzi L. Urine Calcium: Laboratory Measurement and Clinical Utility. Lab Med. 2010;41(11):683-6. doi: 10.1309/LM9SO94ZNBHEDNTM

Chula DC, Campos RP, Emygdio D. Caracterização Clínica dos Pacientes com Hipercalciúria na Nefrolitíase Clinical. J Bras Nefrol. 2006;28(2):72-6.

García Nieto VM, Luis Yanes MI, Tejera Carreño P, Perez Suarez G, Moraleda Mesa T. La hipercalciuria idiopática revisada. ¿Anomalía metabólica o enfermedad? Nefrología. 2019;39(6):592-602. doi: 10.1016/j.nefro.2019.02.011

Ryan LE, Ing SW. Idiopathic hypercalciuria: Can we prevent stones and protect bones? Cleve Clin J Med. 2018;85(1):47–54. doi: 10.3949/ccjm.85a.16090

Dawson CH, Tomson CRV. Kidney stone disease: pathophysiology, investigation and medical treatment. Clin Med. 2012;12(5):467-71. doi: 10.7861/clinmedicine.12-5-467

Liern M. Treatment of idiopathic hypercalciuria and its impact on associated diseases. Arch Argent Pediatr. 2013;111(2):110-4. doi: 10.5546/aap.2013.eng.110

Escribano J, Balaguer A, Roqué i Figuls M, Feliu A, Ferre N. Dietary interventions for preventing complications in idiopathic hypercalciuria. Cochrane Database System Rev. 2014;2014(2). https://doi.wiley.com/10.1002/14651858.CD006022.pub4

Coe FL, Evan A, Worcester E. Pathophysiology-Based treatment of idiopathic calcium kidney stones. Clin J Am Soc Nephrol. 2011;6(8):2083-92. doi: 10.2215/CJN.11321210

Costa C, Gonick HC, Mims MH. Idiopathic hypercalciuria. AMB Rev Assoc Med Bras. 1972;18(5):157-62. Available from: http://www.ncbi.nlm.nih.gov/pubmed/4537900

Downie ML, Alexander RT. Molecular mechanisms altering tubular calcium reabsorption. Pediatr Nephrol. 2021 Apr 1. doi: 10.1007/s00467-021-05049-0

Published

2023-03-31

Issue

Section

Relato de Caso/Case Report

How to Cite

Pigosssi, B. D., Pedroso, I. Q., Mattos, L. O., Dias, J. C. R., & D’Avila, R. (2023). Hyperparathyroidism associated with primary hypercalciuria in a patient with recurrent renal lithiasis. Revista De Medicina, 102(2), e-199863. https://doi.org/10.11606/issn.1679-9836.v102i2e-199863