Cardiovascular effects of free or complexed linalool to β-cyclodextrin: a focus for antihypertensive action
DOI:
https://doi.org/10.11606/issn.1679-9836.v102i6e-203574Keywords:
Hypertension, Cardiovascular diseases, Linalool, Cyclodextrin, Beta- CyclodextrinsAbstract
Introduction: The monoterpene linalool (LIN) has several pharmacological activities, including as an antihypertensive, but it has solubility problems due to its lipophilic character. Thus, stabilization strategies and improvement of pharmacokinetic and pharmacodynamic parameters have been studied, such as the formation of inclusion complexes with cyclodextrins (CDs). Objective: The purpose of this review is to gather information about the cardiovascular effects of LIN and to evaluate the possibility of using CDs to improve the biological properties of LIN. Methodology: This literature review covered articles between 1998 and 2022, collected in the PUBMED, SciELO, LILACS and MEDLINE databases. Results: In normotensive rats, LIN induced hypotension associated with tachycardia while in hypertensive rats, it reduced blood pressure without changing heart rate. LIN has a direct action on the vasculature promoting vasorelaxation and improving cardiac function. Interestingly, complexation of LIN with β-CDs improved the antihypertensive activity of the monoterpene. Conclusion: It was evidenced in this review the pharmacological potential of LIN as a hypotensive, vasorelaxant and antihypertensive agent. Furthermore, there is evidence that it is possible to improve the antihypertensive effect of LIN with the use of inclusion systems with CDs, but additional studies on this topic should be carried out.
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