Evaluation of risk factors for death in COVID-19 patients
Óbito em pacientes com COVID-19
DOI:
https://doi.org/10.11606/issn.1679-9836.v103i6e-212083Keywords:
COVID-19, PandemicAbstract
COVID-19, caused by the novel coronavirus SARS-CoV-2, emerged in December 2019 and quickly became a global public health crisis. The disease has shown a high mortality rate, particularly among the elderly. In Minas Gerais, the pandemic had a significant impact, with Santa Casa de Misericórdia de Passos playing a crucial role in patient care through the Unified Health System (SUS). Patients with comorbidities, such as cardiovascular, cerebrovascular diseases, and diabetes mellitus, exhibited more severe clinical outcomes. Identifying and stratifying risks at hospital admission are essential for improving disease management. This project aims to evaluate serum alterations of biochemical markers in patients diagnosed with COVID-19 at Santa Casa de Misericórdia de Passos. The study sought to correlate biochemical markers evaluated with disease severity, treatment responses, and clinical outcomes, contributing to enhanced preventive and therapeutic strategies against COVID-19.
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References
WHO Coronavirus (COVID-19) Dashboard. https://covid19.who.int
Folha informativa sobre COVID-19 - OPAS/OMS - Organização Pan-Americana da Saúde, https://www.paho.org/pt/covid19 (2021, accessed 17-02 2021).
Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA 2020;323:1239-42. Doi: https://doi.org/10.1001/jama.2020.2648
Gerais SdEdSdM. Boletim Epidemiológico Coronavírus. https://coronavirus.saude.mg.gov.br/boletim
Santa Casa de Misericórdia de Passos. http://www.scmp.org.br/hospital/3/institucional
Guan WJ, Liang WH, Zhao Y, Ling HR, Chen ZS, Li YM, et al. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur Respir J. 2020;55:2000547. Doi: https://doi.org/10.1183/13993003.00547-2020.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;15(395):507-13. 2020/01/30. Doi: https://doi.org/10.1016/S0140-6736(20)30211-7.
Eiras S, Álvarez E, Brión M, Gonzalez-Juanatey JR. COVID-19 and treatment guided by biochemical and molecular diagnostic tests to reduce myocardial damage and cardiotoxicity. Rev Esp Cardiol. 2020;73:691-3. Doi: https://doi.org/10.1016/j.recesp.2020.04.025.
Wang Y, Yan X, Huang C, Sun Y, Yao C, Lin Y, Xiao W. Risk factors of mortality and contribution of treatment in patients infected with COVID-19: a retrospective propensity score matched study. Curr Med Res Opin. 2021;37:13-9. Doi: https://doi.org/10.1080/03007995.2020.1853508.
Chen Y, Klein SL, Garibaldi BT, Li H, Wu C, Osevala NM, et al. Aging in COVID-19: Vulnerability, immunity and intervention. Ageing Res Rev. 2021;65:101205. Doi: https://doi.org/10.1016/j.arr.2020.101205.
Li J, Huang DQ, Zou B, Yang H, Hui WZ, Rui F, et al. Epidemiology of COVID-19: A systematic review and meta-analysis of clinical characteristics, risk factors, and outcomes. J Med Virol. 2021;93:1449-58. Doi: https://doi.org/10.1002/jmv.26424.
Guo A, Lu J, Tan H, Kuang Z, Luo Y, Yang T, et al. Risk factors on admission associated with hospital length of stay in patients with COVID-19: a retrospective cohort study. Sci Rep. 2021;11:7310. Doi: https://doi.org/10.1038/s41598-021-86853-4.
Butt AA, Kartha AB, Masoodi NA, Azad AM, Asaad NA, Alhomsi MU, et al. Hospital admission rates, length of stay, and in-hospital mortality for common acute care conditions in COVID-19 vs. pre-COVID-19 era. Public Health. 2020;189:6-11. Doi: https://doi.org/10.1016/j.puhe.2020.09.010.
Navaratnam AV, Gray WK, Day J, Wendon J, Briggs TWR. Patient factors and temporal trends associated with COVID-19 in-hospital mortality in England: an observational study using administrative data. Lancet Respir Med. 2021;9:397-406. Doi: https://doi.org/10.1016/S2213-2600(20)30579-8.
Yang Y, Lu Q-B, Liu M-J, Wang YX, Z AR, Jalali N, et al. Epidemiological and clinical features of the 2019 novel coronavirus outbreak in China. Cold Spring Harbor Laboratory Press, 2020.
Alahmari AA, Khan AA, Elganainy A, Almohammadi EL, Hakawi AM, Assiri AM, et al. Epidemiological and clinical features of COVID-19 patients in Saudi Arabia. J Infect Public Health. 2021;14:437-43. Doi: https://doi.org/10.1016/j.jiph.2021.01.003.
Du Y, Tu L, Zhu P, Mu M, Wang R, Yang P, et al. Clinical Features of 85 Fatal Cases of COVID-19 from Wuhan. A Retrospective Observational Study. Am J Respir Crit Care Med. 2020;201:1372-9. Doi: https://doi.org/10.1164/rccm.202003-0543OC.
Bienvenu LA, Noonan J, Wang X, Peter K. Higher mortality of COVID-19 in males: sex differences in immune response and cardiovascular comorbidities. Cardiovasc Res. 2020;116:2197-206. Doi: https://doi.org/10.1093/cvr/cvaa284.
White A. Men and COVID-19: the aftermath. Postgrad Med. 2020;132:18-27. Doi: https://doi.org/10.1080/00325481.2020.1823760.
Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, et al. Clinical features and treatment of COVID-19 patients in northeast Chongqing. J Med Virol. 2020;92:797-806. Doi: https://doi.org/10.1002/jmv.25783.
Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z, et al. D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost. 2020;18:1324-9. Doi: https://doi.org/10.1111/jth.14859.
Gao Y, Li T, Han M, Li X, Wu D, Xu Y, et al. Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol. 2020;92:791-6. Doi: https://doi.org/10.1002/jmv.25770.
Investigators C-IGobotRNatC-I. Clinical characteristics and day-90 outcomes of 4244 critically ill adults with COVID-19: a prospective cohort study. Intensive Care Med. 2021;47:60-73. Doi: https://doi.org/10.1007/s00134-020-06294-x.
Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m1091. Doi: https://doi.org/10.1136/bmj.m1091.
Wang F, Hou H, Luo Y, Tang G, Wu S, Huang M, et al. The laboratory tests and host immunity of COVID-19 patients with different severity of illness. JCI Insight. 2020;5. Doi: https://doi.org/10.1172/jci.insight.137799.
Echeverría-Esnal D, Martin-Ontiyuelo C, Navarrete-Rouco ME, Cuscó MDA, Ferrández O, Horcajada JP, Grau S. Azithromycin in the treatment of COVID-19: a review. Expert Rev Anti Infect Ther. 2021;19:147-63. Doi: https://doi.org/10.1080/14787210.2020.1813024.
Arshad S, Kilgore P, Chaudhry ZS, Jacobsen G, Wang DD, Huitsing K, et al. Treatment with hydroxychloroquine, azithromycin, and combination in patients hospitalized with COVID-19. Int J Infect Dis. 2020;97:396-403. Doi: https://doi.org/10.1016/j.ijid.2020.06.099.
Gyselinck I, Janssens W, Verhamme P, Vos R. Rationale for azithromycin in COVID-19: an overview of existing evidence. BMJ Open Respir Res. 2021;8. Doi: https://doi.org/10.1136/bmjresp-2020-000806.
Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. Olfactory and Oral Manifestations of COVID-19: Sex-Related Symptoms-A Potential Pathway to Early Diagnosis. Otolaryngol Head Neck Surg. 2020;163:722-8. Doi: https://doi.org/10.1177/0194599820934380.
Jutzeler CR, Bourguignon L, Weis CV, Tong B, Wong C, Rieck B, et al. Comorbidities, clinical signs and symptoms, laboratory findings, imaging features, treatment strategies, and outcomes in adult and pediatric patients with COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;37:101825. Doi: https://doi.org/10.1016/j.tmaid.2020.101825.
Asselah T, Durantel D, Pasmant E, Lau G, Schinazi RF. COVID-19: Discovery, diagnostics and drug development. J Hepatol. 2021;74:168-84. Doi: https://doi.org/10.1016/j.jhep.2020.09.031.
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Copyright (c) 2024 Maria Eduarda Souza Freire, Maria Clara Del Pintor Pasotti, Vitor Lima de Queiroga, Guilherme Garcia Galdino, Vinicius Brandão Lemes, Rafaela de Souza e Paula, Maria Carolina Yi Lin Lee, Poliana Romão da Silva, Camila Belfort Piantino , Josy Maria Maximiano, Alexandre Beraldo Ordones, Katia Ramos Moreira Leite, Sabrina Thalita dos Reis Faria
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