Outpatient evaluation of the loss of protective plantar sensitivity in patients with type 2 Diabetes Mellitus in a tertiary health care service
DOI:
https://doi.org/10.11606/issn.1679-9836.v104i4e-231487Keywords:
Diabetic foot, Diabetic neuropathy, Diabetes mellitusAbstract
Introduction: Diabetic peripheral neuropathy (DPN) is a frequent but under-recognized complication of diabetes mellitus (DM). Loss of protective sensitivity (LPS) is an important feature of DPN, potentially leading to ulcers and amputations if not detected early. Objective: To determine the prevalence of LPS in individuals with type 2 diabetes (T2DM) in a tertiary healthcare service, correlating it with alterations in nerve fibers, comorbidities, and other risk factors. Methodology: A cross-sectional, exploratory, and descriptive study with a quantitative approach carried out on T2DM patients. Data was collected through anamnesis, clinical examination of the feet, medical record analysis,and by testing various sensitivities. Results: 76 people took part, with an average age of 65.4 years (60.5% women). The average time since DM diagnosis was 17.6 years, and the average glycated hemoglobin was 9.4%. LPS was detected in 15.8% (n=12) of the participants, with 58.3% of whom were men, 58.3% obese, 91.7% hypertensive, 75.0% with diabetic kidney disease (DKD), 33.3% with retinopathy, 50.0% ex-smokers, and 83.4% using insulin. Conclusion: Although few people were affected by PSPP, the data from this study corroborated the literature regarding the association of obesity, arterial disease, DKD, retinopathy, smoking and insulin use with LPS. This reinforces the importance of periodic foot examinations in T2DM patients.
Downloads
References
Ministério da Saúde. Plano de Reorganização da Atenção à Hipertensão arterial e ao Diabetes mellitus. Editora MS; 2002. Doi: https://doi.org/10.1590/S0034-89102001000500014
World Health Organization. Diabetes [Internet]. World Health Organization. 2024. https://www.who.int/health-topics/diabetes#tab=tab_1.
International Diabetes Federation. Brazil [Internet]. International Diabetes Federation. 2021. https://idf.org/our-network/regions-and-members/south-and-central-america/members/brazil/
GBD 2021 Diabetes Collaborators. Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet. 2023;402(10397):203-34. Doi: 10.1016/S0140-6736(25)00053-4.
Carvalho VF, Ueda T, Paggiaro AO, Nascimento ARF, Ferreira MC, Gemperli R. Comparison of neurosensory devices in detecting cutaneous thresholds related to protective sensibility: A cross-sectional study in São Paulo, Brazil. Diabetes Res Clin Pract. 2019;157:107821. Doi: 10.1016/j.diabres.2019.107821.
Appenzeller S. Polineuropatias periféricas. Rev Bras Reumatol Engl Ed. 2015;14(2):5. Doi: 10.46833/reumatologiasp.2015.14.2.21-24
Singh N. Preventing Foot Ulcers in Patients With Diabetes. JAMA. 2005;293(2):217. Doi: 10.1001/jama.293.2.217
Gagliardi ART. Neuropatia diabética periférica [Internet]. J Vasc Bras. 2003;2(1)67-74. https://jvascbras.org/article/5e220d1d0e882507026d0102.
Schmid H, Neumann C, Brugnara L, Schmid H. O diabetes melito e a desnervação dos membros inferiores: a visão do diabetólogo. J Vasc Bras [Internet]. 2020;2(1):37-48. https://www.jvascbras.org/article/5e220c100e8825f97f6d0101.
Moreira RO, Castro AP, Papelbaum M, Appolinário JC, Ellinger VCM, Coutinho WF, et al. Tradução para o português e avaliação da confiabilidade de uma escala para diagnóstico da polineuropatia distal diabética. Arq Bras Endocrinol Metabol 2005;49(6):944-50. Doi: 10.1590/S0004-27302005000600014
Clair C, Cohen MJ, Eichler F, Selby KJ, Rigotti NA. The Effect of Cigarette Smoking on Diabetic Peripheral Neuropathy: A Systematic Review and Meta-Analysis. J Gen Intern Med [Internet]. 2015;30(8):1193-203. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4510224/.
Tesfaye S, Chaturvedi N, Eaton SEM, Ward JD, Manes C, Ionescu-Tirgoviste C, et al. Vascular risk factors and diabetic neuropathy. N Engl J Med [Internet]. 2005;352(4):341–50. https://pubmed.ncbi.nlm.nih.gov/15673800/.
Boulton AJ, Vileikyte L, Ragnarson-Tennvall G, Apelqvist J. The global burden of diabetic foot disease. The Lancet [Internet]. 2005;366(9498):1719-24. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(05)67698-2/fulltext
Balbinot LF. Diagnóstico de neuropatia no diabetes mellitus tipo 2 e no prédiabetes [Tese de Doutorado]. [Universidade Federal do Rio Grande do Sul]; 2012. http://hdl.handle.net/10183/79515
Bahia L. O alto custo do pé diabético no Brasil [Internet]. Sociedade Brasileira de Diabetes. 2020. https://diabetes.org.br/o-alto-custo-do-pe-diabetico-no-brasil-2/.
Moreira ED, Neves RCS, Nunes ZO, de Almeida MCC, Mendes ABV, Fittipaldi JAS, et al. Glycemic control and its correlates in patients with diabetes in Venezuela: Results from a nationwide survey. Diabetes Res Clin Pract.. 2010;87(3):407-14. http://repositorio.unifesp.br/handle/11600/32331
Toscano C, Sugita T, Rosa M, Pedrosa H, Rosa R, Bahia L. Annual Direct Medical Costs of Diabetic Foot Disease in Brazil: A Cost of Illness Study. Int J Environ Res Public Health. 2018;15(1):89 Doi: 10.3390/ijerph15010089
Van Acker K, Bouhassira D, De Bacquer D, Weiss S, Matthys K, Raemen H, et al. Prevalence and impact on quality of life of peripheral neuropathy with or without neuropathic pain in type 1 and type 2 diabetic patients attending hospital outpatients clinics. Diabetes Metab J. 2009;35(3):206-13. https://www.ncbi.nlm.nih.gov/pubmed/19297223.
Khunti K, Chen H, Cid‐Ruzafa J, Fenici P, Gomes MB, Hammar N, et al. Glycaemic control in patients with type 2 diabetes initiating second‐line therapy: Results from the global DISCOVER study programme. Diabetes Obes Metab. 2019;22(1):66-78. Doi: 10.1111/dom.13866
Ramos TTO, Santos MCQ, Lins BS, Melo ÉCA, Santos SMP, Noronha JAF. Avaliação da perda da sensibilidade protetora plantar como diagnóstico precoce da neuropatia diabética. Braz. J. Dev.. 2020;6(5):27500-14. Doi:10.34117/bjdv6n5-266
Patel SY, McCoy RG, Barnett ML, Shah ND, Mehrotra A. Diabetes Care and Glycemic Control During the COVID-19 Pandemic in the United States. JAMA Intern Med. 2021;(10). Doi: 10.1001/jamainternmed.2021.3047
Chisini LA, Castilhos ED de, Costa F dos S, D’Avila OP. Impacto da pandemia COVID-19 no Pré-natal, Diabetes e consulta médica no Sistema Único de Saúde Brasileiro. Rev Bras Epidemiol. 2021;24. https://www.scielo.br/j/rbepid/a/XFbBvgSPLDWSD98vpcS3TRQ/abstract/?format=html&lang=pt.
Raccah D, Chou E, Colagiuri S, Gaàl Z, Lavalle F, Mkrtumyan A, et al. A global study of the unmet need for glycemic control and predictor factors among patients with type 2 diabetes mellitus who have achieved optimal fasting plasma glucose control on basal insulin. Diabetes Metab Res Rev. 2016;33(3):e2858.Doi: 10.1002/dmrr.2858
Tesfaye S, Stevens LK, Stephenson JM, Fuller JH, Plater M, Ionescu-Tirgoviste C, et al. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia. 1996;39(11):1377-84. Doi: 10.1007/s001250050586
Deery HG, Sangeorzan JA. Saving the diabetic foot with special reference to the patient with chronic renal failure. Infect Dis Clin North Am. 2001;15(3):953-81. https://www.sciencedirect.com/science/article/abs/pii/S0891552005701793.
UK. Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet (London, England). 1998;352(9131):837-53. https://pubmed.ncbi.nlm.nih.gov/9742976/.
Aumiller WD, Dollahite HA. Pathogenesis and management of diabetic foot ulcers. JAAPA. 2015;28(5):28-34. https://journals.lww.com/jaapa/fulltext/2015/05000/Pathogenesis_and_management_of_diabetic_foot.6.aspx.
Canata, María Gabriela, Rodríguez, María Gloria, López H, Romero F, Báez S, Ortiz I. Factores de riesgo asociados a Pérdida de Sensibilidad Protectora en pacientes con Diabetes en la Unidad Multidisciplinaria de Pie Diabético. An Univ Nac Asuncion. 2021;61-6. https://pesquisa.bvsalud.org/portal/resource/pt/biblio-1178623.
Swinnen SG, Hoekstra JB, DeVries JH. Insulin Therapy for Type 2 Diabetes. Diabetes Care. 2009;32(suppl_2):S253-9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2811456/.
Wiggin TD, Sullivan KA, Pop-Busui R, Amato A, Sima AAF, Feldman EL. Elevated Triglycerides Correlate With Progression of Diabetic Neuropathy. Diabetes. 2009;58(7):1634-40. Doi: 10.2337/db08-1771
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Fernanda Brandão Montes, Fabiana Alves Carriel, João Carlos Ramos Dias, Lígia Oliveira Mattos , Cristiano G. R. Barcellos, Ituo Teshima Filho , Giane Cristina de Moraes Garcia

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.