Normal pressure hydrocephalus: current view on pathophysiology, diagnosis and treatment

Authors

  • Renan Muralho Pereira Universidade Anhembi Morumbi.
  • Laura Mazeti Universidade Anhembi Morumbi.
  • Deborah Cristina Pereira Lopes Universidade Anhembi Morumbi.
  • Fernando Campos Gomes Pinto Universidade de São Paulo, Faculdade de Medicina, Instituto de Psiquitria

DOI:

https://doi.org/10.11606/issn.1679-9836.v91i2p96-109

Keywords:

Hydrocephalus, normal pressure/physiophatology, normal pressure/therapy, normal pressure/diagnosis, Ventriculoperitoneal shunt, Gait apraxia, Dementia, Urinary incontinence.

Abstract

Introduction: The normal pressure hydrocephalus (NPH), described in 1964 by Salomón Hakim, is an insidious disease that affects mainly elderly people and is manifested by the clinical triad of gait disorders, dementia and urinary incontinence associated with radiological findings of ventriculomegaly and laboratory findings of normal CSF pressure. Objective: present the main hypotheses related to the pathophysiology, imaging diagnosis and treatment of NPH in practice today. Methods: the literature review was conducted through MEDLINE and PubMed, where was used the MeSH resource (Medical Subject Headings) for the selection of articles from the last 6 years. Results: both the pathophysiology and diagnostic criteria of NPH has not been fully established. The main treatment consists of the CSF shunt. Conclusion: it is essential that the diagnosis of NPH be realized early and that patients with higher chance to improve after CSF shunt are identified.

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Author Biographies

  • Renan Muralho Pereira, Universidade Anhembi Morumbi.
    Prêmio Monografias – COMU 2011.Academico da Universidade Anhembi Morumbi, São Paulo, SP; membros da Liga de Neurocirugia da FMUSP.
  • Laura Mazeti, Universidade Anhembi Morumbi.
    Prêmio Monografias – COMU 2011.Academico da Universidade Anhembi Morumbi, São Paulo, SP; membros da Liga de Neurocirugia da FMUSP.
  • Deborah Cristina Pereira Lopes, Universidade Anhembi Morumbi.
    Prêmio Monografias – COMU 2011.Academico da Universidade Anhembi Morumbi, São Paulo, SP; membros da Liga de Neurocirugia da FMUSP.
  • Fernando Campos Gomes Pinto, Universidade de São Paulo, Faculdade de Medicina, Instituto de Psiquitria
    Orientador, Coordenador do Grupo de Hidrodinâmica Cerebral, Divisão de Neurocirurgia Funcional do Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.

References

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Published

2012-06-18

Issue

Vol. 91 No. 2 (2012)

Section

Artigos

How to Cite

Pereira, R. M., Mazeti, L., Lopes, D. C. P., & Pinto, F. C. G. (2012). Normal pressure hydrocephalus: current view on pathophysiology, diagnosis and treatment. Revista De Medicina, 91(2), 96-109. https://doi.org/10.11606/issn.1679-9836.v91i2p96-109