Manifestations in the esophagus in the scleroderma model induced by type V collagen in rabbits

Authors

  • Guilherme Pagin São Julião Universidade de São Paulo, Faculdade de Medicina
  • Diego Daniel Pereira Universidade de São Paulo, Faculdade de Medicina
  • Daniel Marchi dos Anjos Universidade de São Paulo, Faculdade de Medicina
  • Walcy Rosolia Teodoro Universidade de São Paulo, Faculdade de Medicina
  • Natalino Hajime Yoshinari Universidade de São Paulo, Faculdade de Medicina
  • Ana Paula Pereira Velosa Universidade de São Paulo, Faculdade de Medicina

DOI:

https://doi.org/10.11606/issn.1679-9836.v86i3p163-173

Keywords:

Scleroderma, localized, Esophageal diseases, Models, animal, Rabbits, Collagen type V, Disease progression.

Abstract

Backgrounds: Sclerosis systemic that usually affects the esophagus. However its patologic mechanism is still unknown. Objective: Evaluate the manifestation of the esophagus in a experimental model of scleroderma induced by type V collagen in rabbits. Matherial and Methods: 39 rabbits submited to the model immunization were morfologicaly analised. Results: A progressive deposit of collagen fibers was observed in H&E and Tricomico of Masson. Which was confirmed by the imunofluorescence. Conclusion: We concluded that the characteristics observeds are similar to what happens in the esophagus of human, but in an earlier period.

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Author Biographies

  • Guilherme Pagin São Julião, Universidade de São Paulo, Faculdade de Medicina
    Alunos acadêmicos.
  • Diego Daniel Pereira, Universidade de São Paulo, Faculdade de Medicina
    Alunos acadêmicos.
  • Daniel Marchi dos Anjos, Universidade de São Paulo, Faculdade de Medicina
    Alunos acadêmicos.
  • Walcy Rosolia Teodoro, Universidade de São Paulo, Faculdade de Medicina
    Orientadores.
  • Natalino Hajime Yoshinari, Universidade de São Paulo, Faculdade de Medicina
    Orientadores.
  • Ana Paula Pereira Velosa, Universidade de São Paulo, Faculdade de Medicina
    Orientadores.

References

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Published

2007-09-26

Issue

Vol. 86 No. 3 (2007)

Section

Medical Articles

How to Cite

Julião, G. P. S., Pereira, D. D., Anjos, D. M. dos, Teodoro, W. R., Yoshinari, N. H., & Velosa, A. P. P. (2007). Manifestations in the esophagus in the scleroderma model induced by type V collagen in rabbits. Revista De Medicina, 86(3), 163-173. https://doi.org/10.11606/issn.1679-9836.v86i3p163-173