Analysis of myocardial preservation after N2-mercaptopropionylglicin administration in an experimental model of ischemy and reperfusion in dogs
DOI:
https://doi.org/10.11606/issn.1679-9836.v83i1-2p33-45Keywords:
Myocardium, Mercaptoproprionylglycine/pharmacology, Dogs, Myocardial infarctation, Antioxidants/therapeutic use, Disease models, animal, Myocardial reperfusion/methods.Abstract
Nowadays, cardiovascular diseases are the principal cause of morbimortality, specially the coronary artery disease. New physiopathological acknowledgement indicates new mechanisms for myocardial injury, still not quite studied.
The aim of this study is to analyze the effect of N2-Mercaptopropionilglicine (N2-MPG) as a myocardial protection agent during ischemya/reperfusion based on the preservation
of the necrosis area. Sixteen dogs where divided into two groups of eight dogs each one: Group I (N2-MPG) and Group II (control). After the experimental acute myocardial
infarction reproduction, the hearts where colored (TTC/Blue Evans dye) and weighed for the myocardial preservation analysis. The amount of necrosis area were: Group I
(73,14%) and Group II (49,98%) through the Mann-Whitney method. The necrosis area reduction showed an average reduction of 23,16%, concluding that N2-MPG has a
protection effect during myocardial ischemya/reperfusion.
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