Pulmonary functional assessment: longitudinal study after treatment of pulmonary tuberculosis

Authors

  • Marina Pires Nishi Universidade Federal de Minas Gerais, Faculdade de Medicina, Programa de Pós-Graduação das Ciências Aplicadas à Saúde do Adulto, Belo Horizonte, Minas Gerais, Brazil http://orcid.org/0000-0002-6737-9196
  • Eliane Viana Mancuzo Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte, Minas Gerais, Brazil Universidade Federal de Minas Gerais, Hospital das Clínicas, Laboratório de Função Pulmonar, Belo Horizonte, Minas Gerais, Brazil http://orcid.org/0000-0001-7797-7088
  • Nara Sulmonett Universidade Federal de Minas Gerais, Hospital das Clínicas, Laboratório de Função Pulmonar, Belo Horizonte, Minas Gerais, Brazil http://orcid.org/0000-0003-3303-3549
  • Isabela Neves de Almeida Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório de Pesquisa em Micobactérias, Belo Horizonte, Minas Gerais, Brazil Universidade Federal de Ouro Preto, Escola de Farmácia, Departamento de Análises Clínicas, Ouro Preto, Minas Gerais, Brazil http://orcid.org/0000-0001-6152-7648
  • Aina Liz Alves César Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório de Pesquisa em Micobactérias, Belo Horizonte, Minas Gerais, Brazil
  • Silvana Spindola de Miranda Universidade Federal de Minas Gerais, Faculdade de Medicina, Departamento de Clínica Médica, Belo Horizonte, Minas Gerais, Brazil Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório de Pesquisa em Micobactérias, Belo Horizonte, Minas Gerais, Brazil http://orcid.org/0000-0001-7245-4472

DOI:

https://doi.org/10.1590/S1678-9946202163065

Keywords:

Spirometry, 6-minute walk test, Lung capacity, Tuberculosis sequelae

Abstract

Even when treated adequately, pulmonary tuberculosis can lead to pulmonary sequelae. Patients treated for PTB between 2012 and 2016 answered a standardized questionnaire and underwent chest radiography and spirometry, measurement of absolute pulmonary volume, Diffusing Capacity for Carbon Monoxide (DLCO) and the 6-min walk test (6MWT) on two occasions: within the first year after the end of treatment (follow-up 1), and one and two years after follow-up 1 (follow-up 2). A total of 55 patients they underwent spirometry, 23 (41.82%) had obstructive ventilatory disorder (OVD) and eight (14.5%) had moderate OVD. In total, 29 patients underwent pulmonary function tests (PFTs) and 24 patients underwent the 6MWT on two occasions. The functional changes after PTB treatment appear not to have varied between one and two years of follow-up. There was a correlation between low FEV1 and low DLCO (p<0.001); low DLCO and low 6MWT (p<0.001) and radiographic abnormalities and low FEV1 (p=0.033). The most frequently observed change in spirometry was found in patients with OVD.

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Published

2021-09-21

Issue

Vol. 63 (2021)

Section

Original Article

License

Copyright (c) 2021 Marina Pires Nishi, Eliane Viana Mancuzo, Nara Sulmonett, Isabela Neves de Almeida , Aina Liz Alves César , Silvana Spindola de Miranda

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

Nishi, M. P. ., Mancuzo, E. V. ., Sulmonett, N. . ., Almeida , I. N. de, César , A. L. A. ., & Miranda, S. S. de . (2021). Pulmonary functional assessment: longitudinal study after treatment of pulmonary tuberculosis. Revista Do Instituto De Medicina Tropical De São Paulo, 63, e65. https://doi.org/10.1590/S1678-9946202163065