Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings

Authors

  • Thamirys Cosmo Grillo Fajardo Faculdade de Medicina de Jundiaí, Laboratório de Infectologia Pediátrica, Jundiaí, São Paulo, Brazil https://orcid.org/0000-0003-1096-1078
  • Antonio Carlos de Quadros Junior Faculdade de Medicina de Jundiaí, Laboratório de Infectologia Pediátrica, Jundiaí, São Paulo, Brazil https://orcid.org/0000-0003-4936-4342
  • Clóvis Antonio Lopes Pinto Faculdade de Medicina de Jundiaí, Departamento de Morfologia e Patologia Básica, Jundiaí, São Paulo, Brazil; A.C. Camargo Câncer Center, Departamento de Patologia, São Paulo, São Paulo, Brazil https://orcid.org/0000-0003-1711-0081
  • Geovane Ribeiro Dos Santos Faculdade de Medicina de Jundiaí, Departamento de Morfologia e Patologia Básica, Jundiaí, São Paulo, Brazil https://orcid.org/0000-0002-5411-9870
  • Andrea Cristina Botelho da Silva Faculdade de Medicina de Jundiaí, Laboratório de Infectologia Pediátrica, Jundiaí, São Paulo, Brazil https://orcid.org/0009-0006-8092-6656
  • Daniel Thome Catalan Faculdade de Medicina de Jundiaí, Laboratório de Infectologia Pediátrica, Jundiaí, São Paulo, Brazil https://orcid.org/0000-0003-1898-8339
  • Ana Paula Antunes Pascalicchio Bertozzi Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Jundiaí, São Paulo, Brazil; Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Ambulatório de Assistência, Ensino e Pesquisa, Jundiaí, São Paulo, Brazil https://orcid.org/0000-0002-2244-1523
  • Rosa Estela Gazeta Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Jundiaí, São Paulo, Brazil; Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Ambulatório de Assistência, Ensino e Pesquisa, Jundiaí, São Paulo, Brazil https://orcid.org/0000-0003-2527-9880
  • Antonio Fernandes Moron Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Obstetrícia, São Paulo, São Paulo, Brazil; Hospital e Maternidade Santa Joana, Departamento de Medicina Fetal, São Paulo, São Paulo, Brazil https://orcid.org/0000-0002-7963-1758
  • Saulo Duarte Passos Faculdade de Medicina de Jundiaí, Laboratório de Infectologia Pediátrica, Jundiaí, São Paulo, Brazil; Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Jundiaí, São Paulo, Brazil; Faculdade de Medicina de Jundiaí, Departamento de Pediatria, Ambulatório de Assistência, Ensino e Pesquisa, Jundiaí, São Paulo, Brazil https://orcid.org/0000-0002-0908-2677

DOI:

https://doi.org/10.1590/S1678-9946202567043

Keywords:

Arboviruses, Chikungunya virus, Placenta, Pregnancy, Serologic tests

Abstract

Evidence suggests a risk of maternal transmission of chikungunya virus (CHIKV) during the first and third trimesters, potentially leading to miscarriage or neurological consequences for the fetus. This study aimed to conduct a serological survey for CHIKV among women with high-risk pregnancies and analyze neonatal variables and placental tissue alterations. From March 2016 to April 2021, serological, histological, and molecular tests for CHIKV were performed. Blood samples were analyzed for anti-CHIKV IgG and IgM antibodies, and placental tissue was examined for CHIKV RNA and histological changes. Among pregnant patients, 1.33% (7/526) had reactive IgG, and 0.38% (2/526) had IgM/IgG-type antibodies during delivery. Although placental histology of CHIKV disease showed alterations, no viral genetic material was identified in the analyzed tissues. Therefore, further research is needed, including the use of complementary diagnostic techniques, to better understand the impact of this relatively new disease among high-risk pregnant women and newborns.

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Published

2025-07-23

Issue

Vol. 67 (2025)

Section

Brief Communication

License

Copyright (c) 2025 Thamirys Cosmo Grillo Fajardo, Antonio Carlos de Quadros Junior, Clóvis Antonio Lopes Pinto, Geovane Ribeiro Dos Santos, Andrea Cristina Botelho da Silva, Daniel Thome Catalan, Ana Paula Antunes Pascalicchio Bertozzi, Rosa Estela Gazeta, Antonio Fernandes Moron, Saulo Duarte Passos

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Funding data

How to Cite

Fajardo, T. C. G., Quadros Junior, A. C. de, Pinto, C. A. L., Santos, G. R. D., Silva, A. C. B. da, Catalan, D. T., Bertozzi, A. P. A. P., Gazeta, R. E., Moron, A. F., & Passos, S. D. (2025). Serology survey of chikungunya virus in high-risk pregnant women and placental tissue findings. Revista Do Instituto De Medicina Tropical De São Paulo, 67, e43. https://doi.org/10.1590/S1678-9946202567043