Pulmonary thromboembolism in AIDS patient with chronic venous insufficiency, pulmonary tuberculosis and breast cancer: a case report and pathophysiology review

Authors

  • Juan José Cortez-Escalante Universidade de Brasília; Núcleo de Medicina Tropical
  • Cleudson Castro Universidade de Brasília; Núcleo de Medicina Tropical
  • Gustavo Adolfo Sierra Romero Universidade de Brasília; Núcleo de Medicina Tropical
  • Luiza Matos Universidade de Brasília; Núcleo de Medicina Tropical
  • Muhammad Wasif Saif Yale University; School of Medicine; Section of Medical Oncology

Keywords:

Thrombosis, Pulmonary thromboembolism, HIV infection, AIDS, Tuberculosis

Abstract

Recent literature reports thrombotic episodes occurring in patients with HIV infection associated with other abnormalities including neoplasms and infections predisposing to a hypercoagulable state. We report a 47-year-old woman who developed pulmonary thromboembolism in association with HIV infection, pulmonary tuberculosis and breast cancer. She was treated with rifampin, isoniazid, pyrazinamide; heparin, phenprocoumon, zidovudine, lamivudine and efavirenz. Acid fast bacilli were visualized in a sputum smear and three months after, Mycobacterium tuberculosis was isolated from lymph node biopsy during a episode of immune reconstitution. The isolated mycobacteria showed sensitivity to all first-line drugs. HIV infection, breast cancer and pulmonary tuberculosis have several mechanisms that induce hypercoagulable state and can lead to thromboembolic complications. Pulmonary thromboembolism in this patient was a diagnostic challenge because of all the other severe diseases that she experienced at the same time.

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Published

2006-04-01

Issue

Section

Case Reports

How to Cite

Cortez-Escalante, J. J., Castro, C., Romero, G. A. S., Matos, L., & Saif, M. W. (2006). Pulmonary thromboembolism in AIDS patient with chronic venous insufficiency, pulmonary tuberculosis and breast cancer: a case report and pathophysiology review . Revista Do Instituto De Medicina Tropical De São Paulo, 48(2), 105-108. https://revistas.usp.br/rimtsp/article/view/30982