Hyponatremia in visceral leishmaniasis
Keywords:
Hyponatremia, Hypo-osmolality, Hypouricemia, Syndrome of inappropriate antidiuretic hormone secretion, Visceral leishmaniasisAbstract
There are few reports linking hyponatremia and visceral leishmaniasis (kala-azar). This is a study of 55 consecutive kala-azar patients and 20 normal individuals as a control group. Hyponatremia and serum hypo-osmolality were detected in 100% of kala-azar patients. High first morning urine osmolality (750.0 ± 52.0 vs. 894.5 ± 30.0mOsm/kg H2O, p < 0.05), and high 24-hour urine osmolality (426.0 ± 167.0 vs. 514.6 ± 132.0 mOsm/kg H2O, p < 0.05) demonstrated persistent antidiuretic hormone secretion. Urinary sodium was high (82.3 ± 44.2 vs.110.3 ± 34.7 mEq/L, p < 0.05). Low seric uric acid occurred in 61.8% of patients and increased fractional urinary uric acid excretion was detected in 74.5% of them. Increased glomerular filtration rate was present in 25.4% of patients. There was no evidence of extracellular volume depletion. Normal plasma ADH levels were observed in kala-azar patients. No endocrine or renal dysfunction was detected. It is possible that most hyponatremic kala-azar patients present the syndrome of inappropriate antidiuretic hormone secretion.Downloads
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Published
2010-10-01
Issue
Section
Leishmaniasis
How to Cite
Verde, F. A. L., Verde, F. A. L., Veronese, F. J. V., S. Neto, A., Fuc, G., & Verde, E. M. L. (2010). Hyponatremia in visceral leishmaniasis . Revista Do Instituto De Medicina Tropical De São Paulo, 52(5), 253-258. https://revistas.usp.br/rimtsp/article/view/31347