DIARRHEA OUTBREAK IN PERNAMBUCO, BRAZIL, ASSOCIATED WITH A HEAT-STABLE CYTOTOXIC ENTEROTOXIN PRODUCED BY Aeromonas caviae

Autores/as

  • Ana Carolina Amaral LOPES State University of Campinas; Evolution and Bioagents Department
  • Luciano Moura MARTINS Instituto Adolfo Lutz; Enteric and Special Pathogens Infectious Diseases Department
  • Maria Silvia Viccari GATTI State University of Campinas; Evolution and Bioagents Department
  • Cristhiane Moura FALAVINA DOS REIS Fundação Oswaldo Cruz; Instituto Oswaldo Cruz; Bacteriology Department
  • Ernesto HOFER Fundação Oswaldo Cruz; Instituto Oswaldo Cruz; Bacteriology Department
  • Tomomasa YANO State University of Campinas; Evolution and Bioagents Department

Resumen

In the present study enterotoxic and cytotoxic activities of twenty Aeromonas caviaestrains were examined. They originated from fecal specimens of patients with acute diarrhea during an outbreak in Brazil in 2004. Culture supernatants of fourteen strains (70%) caused fluid accumulation in rabbit ileal intestinal loops and in suckling mice assays, and also showed a cytotoxic activity in Vero and Caco-2 cells. The enterotoxic and cytotoxic factors were heat-stable after culture supernatants treatment at 100 ºC. The results revealed that A. caviaestrains produce a putative diarrheagenic virulence factor, a heat-stable cytotoxic enterotoxin that could be linked to the diarrhea outbreak that took place in Brazil.

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Referencias

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Publicado

2015-08-01

Número

Vol. 57 Núm. 4 (2015)

Sección

Bacteriology

Cómo citar

LOPES, A. C. A., MARTINS, L. M., GATTI, M. S. V., FALAVINA DOS REIS, C. M., HOFER, E., & YANO, T. (2015). DIARRHEA OUTBREAK IN PERNAMBUCO, BRAZIL, ASSOCIATED WITH A HEAT-STABLE CYTOTOXIC ENTEROTOXIN PRODUCED BY Aeromonas caviae. Revista Do Instituto De Medicina Tropical De São Paulo, 57(4), 349-351. https://revistas.usp.br/rimtsp/article/view/105548