In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis

Autores

  • Odalys Blanco Centro Nacional de Sanidad Agropecuaria; Grupo de Química-Farmacología-Toxicología
  • Yuliannis Lugones Centro Nacional de Sanidad Agropecuaria; Grupo de Química-Farmacología-Toxicología
  • Elaine Díaz Centro Nacional de Sanidad Agropecuaria; Grupo de Química-Farmacología-Toxicología
  • Lianet Monzote Centro Nacional de Sanidad Agropecuaria; Grupo de Química-Farmacología-Toxicología

Palavras-chave:

Leishmania amazonensis, Pulmonary surfactant, Antibiotic activity, Antimicrobial, SP-B

Resumo

Surfacen® is an exogenous natural lung surfactant, composed by phospholipids and hydrophobic proteins, which is applied successfully in Newborn Respiratory Distress Syndrome. In this paper, in vitro activity of Surfacen® against Leishmania amazonensis is described. The product showed activity against the amastigote form found in peritoneal macrophages from BALB/c mice, with an IC50 value of 17.9 ± 3.0 µg/mL; while no toxic effect on host cell was observed up to 200 µg/mL. This is the first report about the antileishmanial activity of Surfacen®.

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Publicado

2011-08-01

Edição

v. 53 n. 4 (2011)

Seção

Relato Técnico

Como Citar

Blanco, O., Lugones, Y., Díaz, E., & Monzote, L. (2011). In vitro activity of the clinical pulmonary surfactant Surfacen® against Leishmania amazonensis . Revista Do Instituto De Medicina Tropical De São Paulo, 53(4), 235-238. https://revistas.usp.br/rimtsp/article/view/31413