Zygomycosis and Covid-19: a case report and an integrative review

Authors

DOI:

https://doi.org/10.11606/issn.2176-7262.rmrp.2025.221449

Keywords:

Fungal infections, COVID-19, Murcomycosis

Abstract

Objectives: This article aims to describe a case of mucormycosis and provide a brief overview of its association with COVID-19. Methods: A review of the medical literature was performed using Web of Science. The bibliometric survey in the main collection of Web of ScienceTM identified 41 articles. For the development of these articles 668 references were used, with an average of approximately 16 references per article. Results: The medical literature indicates an important link between mucormycosis and COVID, as well as an increased risk of this disease in patients with previous comorbidities, such as diabetes mellitus. There was also a significant increase in the number of cases in the last years of the pandemic. Conclusion: Health care professionals caring for critically ill COVID-19 patients should be aware of opportunistic infections that can complicate the course of the disease.

Downloads

Download data is not yet available.

Author Biographies

  • Andreza Oliveira Alves, Instituto de Educação Superior do Vale do Parnaíba, Faculdade de Ciências Humanas, Exatas e da Saúde do Piauí, Parnaíba, (PI), Brasil

    Graduação em Medicina

  • Lady Jane da Silva Macedo, Instituto de Educação Superior do Vale do Parnaíba, Faculdade de Ciências Humanas, Exatas e da Saúde do Piauí, Parnaíba, (PI), Brasil

    Graduação em Medicina

  • Luana Leal Cosmo Cardoso, Universidade Estadual do Piauí

    Graduação em Odontologia

  • Giuliano da Paz Oliveira, Instituto de Educação Superior do Vale do Parnaíba, Faculdade de Ciências Humanas, Exatas e da Saúde do Piauí, Parnaíba, (PI), Brasil

    Prof. de Neurologia e Medicina do Sono

  • Antonione Santos Bezerra Pinto, Instituto de Educação Superior do Vale do Parnaíba, Faculdade de Ciências Humanas, Exatas e da Saúde do Piauí, Parnaíba, (PI), Brasi

    Prof. de Estomatologia e Patologia Orofacial

References

Alastruey-Izquierdo A, Hoffmann K, de Hoog GS, Rodriguez-Tudela JL, Voigt K, Bibashi E, et al. Species Recognition and Clinical Relevance of the Zygomycetous Genus Lichtheimia (syn. Absidia Pro Parte , Mycocladus ). J Clin Microbiol. 2010 Jun;48(6):2154–70.

Binder U, Maurer E, Lass-Flörl C. Mucormycosis – from the pathogens to the disease. Clin Microbiol Infect. 2014 Jun;20:60–6.

Auberger J, Lass-Florl C, Aigner M, Clausen J, Gastl G, Nachbaur D. Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: real-life data from a single-centre institutional retrospective observational study. J Antimicrob Chemother. 2012 Sep 1;67(9):2268–73.

Danion F, Aguilar C, Catherinot E, Alanio A, DeWolf S, Lortholary O, et al. Mucormycosis: New Developments into a Persistently Devastating Infection. Semin Respir Crit Care Med. 2015 Sep 23;36(05):692–705.

Skiada A, Lass-Floerl C, Klimko N, Ibrahim A, Roilides E, Petrikkos G. Challenges in the diagnosis and treatment of mucormycosis. Med Mycol. 2018 Apr 1;56(suppl_1):S93–101.

Al-Tawfiq JA, Alhumaid S, Alshukairi AN, Temsah MH, Barry M, Al Mutair A, et al. COVID-19 and mucormycosis superinfection: the perfect storm. Infection. 2021 Oct;49(5):833–53.

PATRÍCIA FRAGA BARROS. MUCORMICOSE ORAL: RELATO DE CASO CLÍNICO. 2018.

Garg D, Muthu V, Sehgal IS, Ramachandran R, Kaur H, Bhalla A, et al. Coronavirus Disease (Covid-19) Associated Mucormycosis (CAM): Case Report and Systematic Review of Literature. Mycopathologia. 2021 May;186(2):289–98.

Monte Junior ES do, Santos MEL dos, Ribeiro IB, Luz G de O, Baba ER, Hirsch BS, et al. Rare and Fatal Gastrointestinal Mucormycosis (Zygomycosis) in a COVID-19 Patient: A Case Report. Clin Endosc. 2020 Nov 30;53(6):746–9.

Prabhu S, Alqahtani M, Al Shehabi M. A fatal case of rhinocerebral mucormycosis of the jaw after dental extractions and review of literature. J Infect Public Health. 2018 May;11(3):301–3.

Pandiar D, Kumar NS, Anand R, Kamboj M, Narwal A, Shameena PM. Does COVID 19 generate a milieu for propagation of mucormycosis? Med Hypotheses. 2021 Jul;152:110613.

Brettholz AM, Mccauley SO. Mucormycosis: Early Identification of a Deadly Fungus. J Pediatr Oncol Nurs. 2018 Jul;35(4):257–66.

Mekonnen ZK, Ashraf DC, Jankowski T, Grob SR, Vagefi MR, Kersten RC, et al. Acute Invasive Rhino-Orbital Mucormycosis in a Patient With COVID-19-Associated Acute Respiratory Distress Syndrome. Ophthal Plast Reconstr Surg. 2021 Mar;37(2):e40–80.

Downloads

Published

2025-12-16

Issue

Section

Relato de Caso

How to Cite

1.
Alves AO, Macedo LJ da S, Cardoso LLC, Oliveira G da P, Pinto ASB. Zygomycosis and Covid-19: a case report and an integrative review. Medicina (Ribeirão Preto) [Internet]. 2025 Dec. 16 [cited 2026 Feb. 6];58(2):e-221449. Available from: https://revistas.usp.br/rmrp/article/view/221449