Acute viral bronchiolitis hospitalizations in children in Brazil: a longitudinal study

Authors

DOI:

https://doi.org/10.11606/issn.2176-7262.rmrp.2025.225770

Keywords:

Viral bronchiolitis, Hospital costs, Unified Health System, Health information systems

Abstract

Introduction: Acute viral bronchiolitis (AVB) is a condition that occurs with high incidence in the first years of life, with the main cause being lower respiratory tract infections in young children. The severity of this condition impacts both the extent of internationalization and hospital expenses. Objective: To evaluate the temporal distribution of the epidemiological elements of pediatric hospitalizations due to acute viral bronchiolitis in the Brazilian Unified Health System (SUS). Method: This refers to an observational study based on a population database, thru a retrospective, longitudinal, and epidemiological analysis of information obtained from the Department of Informatics of the Unified Health System (DATASUS) in Brazil, conducted between the years 2012 and 2021, employing descriptive statistics and the application of the Tukey test. Population group consisting of pediatric patients under one year old and those aged between one and four years. Results: The predominance of international average values for the diagnosis of acute bronchiolitis is observed in the Southeast region, with an index of 3,434.9. In the length of stay, the highest significance in the Northeast region was 3.1 days. The most significant rates of hospitalization were recorded in children under 1 year old. Men showed a higher preference regarding the number of hospitalizations, reaching an average of 1,456. Moreover, the average number of deaths resulting from the diagnosis of acute viral bronchiolitis with greater frequency was observed in the Southeast region. Conclusion: The divergences in epidemiological aspects identified in different regions favor the improvement of the implementation of proactive public policies in primary care, aimed at mitigating the risks related to the diseases.

Downloads

Download data is not yet available.

Author Biographies

  • Simone Isidoro Prado, Universidade Federal de São Paulo, São Paulo, (SP), Brasil

    Doutoranda

  • Maykon Anderson Pires de Novais, Federal University of São Paulo

    PhD. Professor Afiliado

References

1. Tan, J., Wu, J., Jiang, W. et al. Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou. BMC Infect Dis 21, 135 (2021). https://doi.org/10.1186/s12879-021-05772-x

2. Del Toro Rodríguez Liliam Beatriz, Martínez Benítez Iliana, Martínez Morales Iselis, Garcia Aguilera Ania, Diéguez Avid Maria Andrea. Clinical-epidemiological characterization of bronchiolitis in pediatric patients. Multimed [Internet]. April 2021, 25 (2): e1448.

3. Luo G, Stone BL, Johnson MD, Nkoy FL. Predicting appropriate admission of bronchiolitis patients in the emergency department: rationale and methods. JMIR Res Protoc. 2016;5(1):e41.

4. Joel Ledbetter, Lance Brannman, Sally W. Wade, Tara Gonzales & Amanda M. Kong (2020) Healthcare resource utilization and costs in the 12 months following hospitalization for respiratory syncytial virus or unspecified bronchiolitis among infants, Journal of Medical Economics, 23:2, 139-147, Doi: 10.1080/13696998.2019.1658592

5. House SA, Marin JR, Hall M, Ralston SL. Trends Over Time in Use of Non recommended Tests and Treatments Since Publication of the American Academy of Pediatrics Bronchiolitis Guideline. JAMA Netw Open. 2021; 4(2):e2037356. Doi: 10.1001/jamanetworkopen.2020.37356.

6. Alnajjar et al. Clinical characteristics and outcomes of children with COVID-19 in Saudi Arabia. Saudi Med J 2021; Vol. 42 (4).

7. Hasegawa K, Tsugawa Y, Brown DF, et al. Trends in bronchiolitis hospitalizations in the United States, 2000-2009. Pediatrics. 2013; 132(1): 28–36.

8. OMS. Organização Mundial de Saúde. The Global Impact of Respiratory Disease – Second Edition Forum of International Respiratory Societies. Disponívelem:https://www.who.int/gard/publications/The_Global_Impact_of_Respiratory_ Disease_POR.pdf. Acess on: 10 de May of 2023.

9. Balekian DS, Linnemann RW, Hasegawa K, et al. Cohort study of severe bronchiolitis during infancy and risk of asthma by age 5 years. J Allergy Clin Immunol Pract 2017; 5:92–6.

10. Paramore, C. et al. Economic Impact of Respiratory Syncytial Virus –related illness in the US. Pharmacoeconomics. 2004; 22(5): 275-84.

11. Naves KC. Critical analysis of the treatment given to children with respiratory syncytial virus infection in a public hospital [dissertation]. São Paulo: Faculty of Medicine of the University of São Paulo; 2018.

12. Borges AM et al.Non-invasive mechanical ventilation in acute viral bronchiolitis: a retrospective cohort study. Electronic Journal of Science & Health, Oct.-Dec. 2017; 10(4):232-238.

13. Carvalho, Werther Brunow de, Johnston, Cíntia e Fonseca, Marcelo Cunio. Acute bronchiolitis, an updated review. Journal of the Brazilian Medical Association [online]. 2007, vol. 53, no. 2 [Accessed November 28, 2022] pp. 182-188.Available at:<https://doi.org/10.1590/S0104-42302007000200027>. Epub 18 Jan 2008. ISSN 1806-9282. https://doi.org/10.1590/S0104-42302007000200027

14. Friedrich F, Ongaratto R, Scotta MC, Veras TN, Stein RT, Lumertz MS, Jones MH, Comaru T, Pinto LA. Early Impact of Social Distancing in Response to Coronavirus Disease 2019 on Hospitalizations for Acute Bronchiolitis in Infants in Brazil. Clin Infect Dis. 2021 Jun 15; 72(12):2071-2075. doi: 10.1093/cid/ciaa1458. PMID: 32986818; PMCID: PMC7543304.

15. Montejo M, Sánchez A, Paniagua N, Saiz-Hernando C, Benito J. Reduction in the incidence of acute bronchiolitis and related hospital admissions during the COVID-19 pandemic. An Pediatr (Engl Ed). 2022 Jun; 96(6):537-539. doi: 10.1016/j.anpede.2022.03.003. Epub 2022 Mar 11. PMID: 35637146; PMCID: PMC8913341.

16. Clinical-epidemiological behavior of acute bronchiolitis in admitted infants. Belmopan, Belize. 2015. MULTIMED [Internet journal]. 2017 [cited 28 Nov 2022];21(3):[approx.15p.].Availableat:http://www.revmultimed.sld.cu/index.php/mtm/article/view/534

17. Meissner HC. Viral Bronchiolitis in Children. N Engl J Med. 2016; 374(1):62-72.

18. Joel Ledbetter, Lance Brannman, Sally W. Wade, Tara Gonzales & Amanda M. Kong (2020) Healthcare resource utilization and costs in the 12 months following hospitalization for respiratory syncytial virus or unspecified bronchiolitis among infants, Journal of Medical Economics, 23:2, 139-147, Doi: 10.1080/13696998.2019.1658592

19. Thaís Carollo Fernandes M, Medeiros Paungartner L, dos Santos Rosa R. Hospitalizations for acute bronchiolitis in the public network of the Metropolitan Region of Porto Alegre – RS from 2012 to 2014. R. Electr. Sci. of Uergs [Internet]. August 27, 2021 [cited April 16, 2023];7(2):196-02. Available at: http://revista.uergs.edu.br/index.php/revuergs/article/view/3006

20. Combret Y, Prieur G, LE Roux P, Médrinal C. Non-invasive ventilation improves respiratory distress in children with acute viral bronchiolitis: a systematic review. Minerva Anestesiol. 2017 Jun;83(6):624-637. doi: 10.23736/S0375-9393.17.11708-6. Epub 2017 Feb 13. PMID: 28192893.

21. Alvarez AE et al. Epidemiological and genetic characteristics associated with the severity of acute viral bronchiolitis by respiratory syncytial virus.J Pedi.atr (Rio J). 2013; 89(6):531−543.

22. Agüera M, Melé-Casas M, Molina MM, Pons-Odena M, de-Sevilla MF, García-García JJ, Launes C, Monfort L. Safety and effectiveness of bubble continuous positive airway pressure as respiratory support for bronchiolitis in a pediatric ward. Eur J Pediatr. 2022 Dec; 181(12):4039-4047. Doi: 10.1007/s00431-022-04616-3. Epub 2022 Sep 21. PMID: 36129536; PMCID: PMC9649485.

23. Paiva VMD, Falcão MC, Matsushita F, Yoshimoto CE. Sazonalidade da bronquiolite em recém-nascidos e lactentes jovens em tempos de pandemia pelo SARS-CoV-2. Resid Pediatr. 2021; 11(2):1-5 DOI: 10.25060/residpediatr-2021.v11n2-610.

24. Brazil. Resolution No. 510, of April 7, 2016. Ethics in Research in the field of Human and Social Sciences. Official Gazette of the Union, Brasília (DF), May 24. 2016.

25. Brazil. Law No. 12,527, of November 18, 2011. Regulates access to information provided for in item XXXIII of art. 5, item II of § 3 of art. 37, and § 2 of art. 216 of the Federal Constitution; amends Law No. 8,112, of December 11, 1990; repeals Law No. 11,111, of May 5, 2005, and provisions of Law No. 8,159, of January 8, 1991; and provides other measures. Official Gazette of the Union, Brasília (DF), November 18. 2011.

26. Soares, M. C., Araújo, J. P. C., Pontes, J. S., Costa, S. de S., Araujo, A. C. R. de A. e, Cantanhede, K. R. M., Vinent, P. R. S., Souza, A. C. L. de, & Marques, C. P. C. (2024). Hospital morbidity of Acute Bronchitis and Acute Bronchiolitis in children in Brazil from 2017 to 2021CONTRIBUCIONES A LAS CIENCIAS SOCIALES, 17(7), 8493. https://doi.org/10.55905/revconv.17n.7-249.

27. Kashiwakura HK, Gonçalves A de O, Azevedo RR de, Nunes A, Silva CAT. Portrait of primary care in Brazil: costs and infrastructure in Brazilian municipalities. Collective health sciences [Internet]. 2021;26:3397–408. Available from: https://doi.org/10.1590/1413-81232021269.2.37112019.

28. Manti et al. UPDATE ‑ 2022 Italian guidelines on the management of bronchiolitis in infants. Italian Journal of Pediatrics (2023) 49:19. https://doi.org/10.1186/s13052-022-01392-6.

29. Sanjay Mahant; et al. Sociodemographic Factors and Trends in Bronchiolitis-Related Emergency Department Visit and Hospitalization Rates. JAMA Network Open. 2024;7(4): e248976. Doi: 10.1001/jamanetworkopen.2024.8976.

Downloads

Published

2026-03-31

Issue

Section

Original Articles

How to Cite

1.
Prado SI, Novais MAP de. Acute viral bronchiolitis hospitalizations in children in Brazil: a longitudinal study. Medicina (Ribeirão Preto) [Internet]. 2026 Mar. 31 [cited 2026 Apr. 1];58(4):e-225770. Available from: https://revistas.usp.br/rmrp/article/view/225770