Linear lichen planus after COVID-19 vaccination
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2025.227774Keywords:
Lichen planus, COVID-19, Drug-related side effects and adverse reactions, Vaccination, Case reportsAbstract
The side effects of COVID-19 vaccines are increasingly being documented, including cutaneous manifestations. In this case report, we describe a 49-year-old female patient who developed pruritic, violaceous, linear lesions on her left lower limb following COVID-19 vaccination. A biopsy confirmed the diagnosis of linear lichen planus, a rare variant of the disease, which was treated with topical clobetasol, resulting in a good response. Although lichen planus has an unknown etiology, COVID-19 vaccination may act as a triggering factor, possibly due to an intense inflammatory response. Monitoring adverse effects is crucial to minimize patient discomfort and maintain confidence in mass vaccination.
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1. Wang H, Paulson KR, Pease SA, Watson S, Comfort H, Zheng P, et al. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet. 2022;399(10334):1513–36.
2. Merhy R, Sarkis AS, Kaikati J, El Khoury L, Ghosn S, Stephan F. New-onset cutaneous lichen planus triggered by COVID-19 vaccination. J Eur Acad Dermatology Venereol. 2021;35(11):e729–30.
3. Kroumpouzos G, Paroikaki ME, Yumeen S, Bhargava S, Mylonakis E. Cutaneous Complications of mRNA and AZD1222 COVID-19 Vaccines: A Worldwide Review. Microorganisms. 2022;10(3).
4. Mcmahon DE, Amerson E, Rosenbach M, Lipoff JB. Cutaneous reactions reported after Moderna and Pfizer COVID-19 vaccination: A registry-based study of 414 cases. J Am Acad Dermatol. 2021;85(1):46–55.
5. Zou H, Daveluy S. Lichen planus after COVID-19 infection and vaccination. Arch Dermatol Res [Internet]. 2023;315(2):139–46. Available from: https://doi.org/10.1007/s00403-022-02497-y
6. Kato J, Kamiya T, Handa T, Kobayashi E, Hida T, Yamashita T, et al. Linear lichen planus after COVID-19 vaccination. Australas J Dermatol. 2022;63(4):e385–7.
7. Williner ME, Inza M, Garay IS, Kurpis M, Lascano AR. Liquen plano lineal Blashkoide, reporte de 2 casos. Rev argent dermatol [Internet]. 2019;100(4):108–9. Available from: https://rad-online.org.ar/2020/01/28/liquen-plano-lineal-blashkoide-reporte-de-2-casos/
8. Castillo JG, Goma FJ de la T, Aguirre AS. Lichen planus after SARS-CoV-2 infection treated with lopinavir/ritonavir. Med Clin (Barc). 2021;156:468–9.
9. Lehman JS, Tollefson MM, Gibson LE. Lichen planus. Int J Dermatol. 2009;48(7):682–94.
10. Herzum A, Burlando M, Molle MF, Micalizzi C, Cozzani E, Parodi A. Lichen planus flare following COVID-19 vaccination: A case report. Clin Case Reports. 2021;9(12):10–2.
11. Diab R, Araghi F, Gheisari M, Kani ZA, Moravvej H. Lichen planus and lichen planopilaris flare after COVID-19 vaccination. Dermatol Ther. 2022;35(3):e15283.
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Copyright (c) 2026 Isabela Sella Sartorelli, Marilda Aparecida Milanez Morgado de Abreu
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