Adiponectinemia and physiological indicators in obese asthmatics and non-asthmatics adolescents

Abstract

Background: Considered a public health problem, obesity has been cited as a risk factor for the development of asthma. Thus, the overweight has influence on the smooth muscle function and induce systemic inflammation of the airways through the adipocytokines. Although adiponectin is considered an antiinflammatory cytokine, since their concentrations decrease in obesity. The literature has show minimal evidence of this behavior before adipocytokine factors involved in the relationship of obesity and asthma. Thus, the present study aimed to analyze the behavior of adiponectinemia responses and physiological parameters in obese asthmatics and non-asthmatics. Methods: Participated 15 obese adolescents (six asthmatics and nine non-asthmatics), submitted anthropometric measurements, cardiorrespiratory, spirometric and laboratory. The diagnosis of asthma has been through clinical history and ISAAC questionnaire, and obesity as BMI above the 95th percentile. We used the bronchoprovocation test with exercise for assessing exercise-induced bronchospasm (EIB). Results: There was difference in % Fall FEV1(P=0.034) among obese asthmatics and non-asthmatics. For obese asthmatics, the coefficient of determination(R2) demonstrated effect of adiponectin with SBP (r=-0.512, R2=0.105), HDL (r=+0.659, R2=0.292),glucose (r=-0.599; R2=0.199), glucose120 (r=-0.686, R2=0.338), insulin120 (r=-0.614, R2=0.221), Absolute VO2max (r=+0.518, R2=0.086), VO2max Relative FFM (r=+0.585; R2=0.178) and % FEV1 (r=+0.580,R2=0.171). In obese non-asthmatics were effects of adiponectin with insulin (r=-0.731, R2 =0.525), HOMAIR(r=-0.684, R2=0.469), QUICKI (r=+0.683, R2=0.535) and VO2max Relative FFM (r=+0.654, R2=0.346).Conclusion: There were likely effects of adiponectinemia responses with physiological indicators associated with overweight and low cardiorespiratory fitness in obese asthmatics and non-asthmatics. Furthermore,for the obese asthmatic adiponectinemia demonstrated a possible effect relationship with %FEV1.