Hyperglycemia and Muscle Mobility in Critically Ill Patients with Sepsis: Historical Hospital-Based Cohort
DOI:
https://doi.org/10.11606/issn.2176-7262.rmrp.2025.218334Palabras clave:
Glycemia, Sepsis, Polyneuropathies, Muscle weaknessResumen
Objectives: Assess the influence of hyperglycemia on the mobility of critical care patients with sepsis. Methods: Cohort study analyzed patients admitted to the ICU (Intensive Care Unit) of Unimed Hospital Center (Joinville, Brazil) from December 2017 to August 2021. Included participants over 18 years old who survived sepsis, with a previous ICU Mobility Scale (IMS) of 10, and without neuromuscular or joint diseases. The mean glycemic levels were measured in the first week of ICU admission and stratified into two levels (group 1 ≤180mg/dl; group 2 >180mg/dl). The outcome mobility was considered low when IMS<6 at ICU discharge. Variables were analyzed using uni and multivariate logistic regression. Results: Of the 307 patients analyzed, 45% were 60 years or older, 53% were male, and 76 patients (24,8%) were in group 2 in glycemic level. There was an increase in prevalence of IMS<6 at group 2 compared to group 1 (60,5%% vs. 49,3%; p=0,091). After adjusting the multivariate model, increasing age, body mass index and mechanical ventilation, as well as COVID-19 at ICU admission, remained related to IMS<6 at ICU discharge. Those with mean glycemic >180mg/dl during the first week of ICU were 85% more likely to have IMS<6 (OR=1,85; IC95% 1,01-3,44; p=0,042). Conclusion: Mean values above 180mg/dl of glycemia in the first week of ICU are associated with worse mobility in ICU survivors of sepsis.
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Derechos de autor 2026 Marina Borges Wageck Horner, Daniela Delwing-de Lima, Glauco Adrieno Westph, Helbert do Nascimento Lima
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
