Cancer mortality in the Capitals and in the interior of Brazil: a four-decade analysis
DOI:
https://doi.org/10.11606/s1518-8787.2020054002255Keywords:
Neoplasms, epidemiology, Mortality, trends, Time Series Studies, Health Status DisparitiesAbstract
OBJECTIVE: to describe the trend of mortality from general cancer and more frequent types among men and women living in the Capitals and other municipalities of the five macro-regions of Brazil between 1978 and 2017. METHODS: Time series study with mortality data corrected by redistribution of ill-defined causes. Proportional cancer mortality was calculated for Brazil and regions. The annual percentage change in rates for total cancer and specific types in each segment and in the selected unit of analysis was calculated by generalized linear regression with Gaussian binding. RESULTS: the proportion of cancer increased progressively for both sexes from 1978 to 2017. Important differences between the Capitals and the interior of the macro-regions were seen with disaggregated data. The greatest declines occurred for stomach cancer, except in the northern and interior regions of the Northeast, and for the cervix cancer, with a generalized fall, with the exception of the interior of the northern region. Lung cancer decreased among men in the Southeast and South regions and had a generalized increase among women. Breast and prostate cancers tended to decrease in the Southeast and South regions and among residents of the Capitals but showing an increase in the interior of the North and Northeast regions. Colorectal cancer had a general tendency to increase; with stability among men in the Capitals of the South region and among women of the Southeast and Midwest regions and, since 2007, a decrease among women in the South region. CONCLUSIONS: Cancer mortality showed great variation among residents of capitals and the interior of the country’s major regions. Clear decrease in mortality was seen for the main types in the Southeast and South regions. The North and Northeast regions have patterns compatible with cancers associated with poverty, while the large increase of the cancers related to sedentary lifestyle stand out.
References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global Cancer Statistics 2018: GLOBOCAN estimates of Incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492
Ferlay J, Soerjomaratam I, Dikshit R, Eser S, Mathers C, Rebelo M, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359-86. https://doi.org/10.1002/ijc.29210
Hashim D, Boffetta P, La Vecchia C, Rota M, Bertuccio P, Malvezzi M, et al. The global decrease in cancer mortality: trends and disparities. Ann Oncol. 2016;27(5):926-33. https://doi.org/10.1093/annonc/mdw027
Bray F, Jemal A, Grey N, Ferlay J, Forman D. Global cancer transitions according to the Human Development Index (2008–2030): a population-based study. Lancet Oncol. 2012;13(8):790-801. https://doi.org/10.1016/S1470-2045(12)70211-5
Azevedo e Silva G, Gamarra CJ, Girianelli VR, Valente JG. A tendência da mortalidade por câncer nas capitais e interior do Brasil entre 1980 e 2006. Rev Saude Publica. 2011;45(6):1009-18. https://doi.org/10.1590/S0034-89102011005000076
Guerra MR, Bustamante-Teixeira MT, Corrêa CSL, Abreu DMX, Curado MP, Mooney M, et al. Magnitude and variation of the burden of cancer mortality in Brazil and Federation Units, 1990 and 2015. Rev Bras Epidemiol. 2017;20 Supl 1:102-19. https://doi.org/10.1590/1980-5497201700050009
Ministério da Saúde (BR), Secretaria de Vigilância em Saúde, Departamento de Vigilância de Doenças e Agravos Não Transmissíveis e Promoção da Saúde. Saúde Brasil 2014: uma análise da situação de saúde e das causas externas. Brasília, DF; 2015. A vigilância do óbito no Brasil: trajetória de 2008 a 2015; p.45-67.
Ministério da Saúde (BR), Secretaria Nacional de Ações Básicas de Saúde, Divisão Nacional de Epidemiologia. Estatísticas de mortalidade: Brasil 1978. Brasília, DF: Centro de Documentação do Ministério da Saúde; 1984.
Ministério da Saúde (BR), Departamento de Informática do Sistema Único de Saúde. Estatísticas vitais, demográficas e socioeconômicas. Brasília, DF; 2017 [cited 2019 May 15]. Available from: http://datasus.saude.gov.br/informacoes-de-saude/tabnet
Mathers CD, Bernard C, Iburg KM, Inoue M, Fat DM, Shibuya K, et al. Global burden of disease in 2002: data sources, methods and results. Geneva: World Health Organization; 2003 [cited 2019 22]. (GPE Discussion Paper, 54). Available from: https://www.who.int/healthinfo/paper54.pdf
Girianelli VR, Gamarra CJ, Azevedo e Silva G. Os grandes contrastes da mortalidade por câncer do colo do útero e de mama no Brasil. Rev Saude Publica. 2014,48(3):459-67. https://doi.org/10.1590/S0034-8910.2014048005214
França E, Teixeira R, Ishitani L, Duncan BB, Cortez-Escalante JJ, Morais Neto OL, et al. Ill-defined causes of death in Brazil: a redistribution method based on the investigation of such causes. Rev Saude Publica. 2014;48(4):671-81. https://doi.org/10.1590/S0034-8910.2014048005146
Gamarra CJ, Valente JG, Silva GA. Correção da magnitude da mortalidade por câncer do colo do útero no Brasil, 1996-2005. Rev Saude Publica. 2010;44(4):629-38. https://doi.org/10.1590/S0034-89102010000400006
Segi M. Cancer mortality for selected sites in 24 countries (1950-57). Senda (JPN): Tohoku University School of Public Health; 1960.
Pinheiro J, Bates D, DebRoy S, Sarkar D; R Core Team. “nlme”: linear and nonlinear mixed effects models. R package version 3.1-140. Vienna (AUS); 2019 [cited 2019 Nov 22]. Available from: https://CRAN.R-project.org/package=nlme
Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros M, et al, editors. Global Cancer Observatory: Cancer Today. Lyon (FR): International Agency for Research on Cancer; 2018. [cited 2019 Nov 22]. Available from: https://gco.iarc.fr/today
Torre LA, Siegel RL, Ward EM, Jemal A. Global Cancer Incidence and Mortality Rates and Trends: an update. Cancer Epidemiol Biomarkers Prev. 2016;25(1):16-27. https://doi.org/10.1158/1055-9965.EPI-15-0578
Welch HG, Kramer BS, Black WC. Epidemiologic signatures in cancer. N Engl J Med. 2019;381(14):1378-86. https://doi.org/10.1056/NEJMsr1905447
Karanikolos M, Ellis L, Coleman MP, McKee M. Health systems performance and cancer outcomes. J Natl Cancer Inst Monogr. 2013;2013(46):7-12. https://doi.org/10.1093/jncimonographs/lgt003
Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019;14(1):26-38. https://doi:10.5114/pg.2018.80001
Instituto Nacional de Câncer (BR), Coordenação Geral de Ações Estratégicas, Divisão de Apoio à Rede de Atenção Oncológica. Diretrizes brasileiras para o rastreamento do câncer do colo do útero. Rio de Janeiro: INCA; 2011 [cited 2019 15]. Available from: http://bvsms.saude.gov.br/bvs/publicacoes/inca/rastreamento_cancer_colo_utero.pdf
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7-34. https://doi.org/10.3322/caac.21551
Szwarcwald CL, Souza Júnior PRB, Marques AP, Almeida WS, Montilla DER. Inequalities in healthy life expectancy by Brazilian geographic regions: findings from the National Health Survey, 2013. Int J Equity Health. 2016;15(1):141. https://doi.org/10.1186/s12939-016-0432-7
Programa das Nações Unidas para o Desenvolvimento (PNUD). Desenvolvimento humano nas macrorregiões brasileiras: 2016. Brasília, DF: PNUD, IPEA, FJP; 2016.
GBD 2016 Brazil Collaborators. Burden of disease in Brazil, 1990-2016: a systematic subnational analysis for the Global Burden of Disease Study 2016. Lancet. 2018;392(10149):760-75. https://doi.org/10.1016/S0140-6736(18)31221-2
Vaccarella S, Laversanne M, Ferlay J, Bray F. Cervical cancer in Africa, Latin America and the Caribbean and Asia: regional inequalities and changing trends. Int J Cancer. 2017;141(10):1997-2001. https://doi.org/10.1002/ijc.30901
Vaccarella S, Franceschi S, Bray F. The incremental benefits of implementing effective cervical cancer screening. Int J Cancer. 2016;138(1):254-5. https://doi.org/10.1002/ijc.29700
Victora CG, Barreto ML, Leal MC, Monteiro CA, Schmidt MI, Paim JS, et al. Health conditions and health-policy innovations in Brazil: the way forward. Lancet. 2011;377(9782):2042-53. https://doi.org/10.1016/S0140-6736(11)60055-X
Santos-Silva I, De Stavola BL, Renna Junior NL, Nogueira MC, Aquino EML, Bustamante-Teixeira MT, Azevedo e Silva G. Ethnoracial and social trends in breast cancer staging at diagnosis in Brazil, 2001-14: a case only analysis. Lancet Glob Health. 2019;7(6):e784-97. https://doi.org/10.1016/S2214-109X(19)30151-2
Stopa SR, Malta DC, Monteiro CN, Szwarcwald CL, Goldbaum M, Cesar CLG. Acesso e uso de serviços de saúde pela população brasileira, Pesquisa Nacional de Saúde 2013. Rev Saude Publica. 2017;51 Supl 1:3s. https://doi.org/10.1590/s1518-8787.2017051000074
Rawla P. Epidemiology of prostate cancer. World J Oncol. 2019;10(2):63-89. https://doi.org/10.14740/wjon1191
Baade PD, Youlden DR, Krnjacki LJ. International epidemiology of prostate cancer: geographical distribution and secular trends. Mol Nutr Food Res. 2009;53(2):171-84. https://doi.org/10.1002/mnfr.200700511
Malta DC, Moura L, Souza MFM, Curado MP, Alencar AP, Alencar GP. Tendência da mortalidade por câncer de pulmão, traquéia e brônquios no Brasil, 1980-2003. J Bras Pneumol. 2007;33(5):536-43. https://doi.org/10.1590/S1806-37132007000500008
Azevedo e Silva G, Noronha CP, Santos MO, Oliveira JFP. Diferenças de gênero na tendência de mortalidade por câncer de pulmão nas macrorregiões brasileiras. Rev Bras Epidemiol. 2008;11(3):411-9. https://doi.org/10.1590/S1415-790X200800030000818 Cancer mortality in Brazil Azevedo e Silva et al.
Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683-91. https://doi.org/10.1136/gutjnl-2015-310912
Malta DC, Vieira ML, Szwarcwald CL, Caixeta R, Brito SMF, Reis AAC. Tendência de fumantes na população brasileira segundo a Pesquisa Nacional de Amostra de Domicílios 2008 e a Pesquisa Nacional de Saúde 2013. Rev Bras Epidemiol. 2015;18 Supl 2:45-56. https://doi.org/10.1590/1980-5497201500060005
Lega IC, Lipscombe LL. Review: diabetes, obesity and cancer-pathophysiology and clinical implications. Endocr Rev. 2020;41(1):33-52. https://doi.org/10.1210/endrev/bnz014
Global Burden of Disease Cancer Collaboration. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017: a systematic analysis for the Global Burden of Disease Study. JAMA Oncol. 2019;5(12):1749-68. https://doi.org/10.1001/jamaoncol.2019.2996
Bigoni A, Antunes JLF, Weiderpass E, Kjærheim K. Describing mortality trends for major cancer sites in 133 intermediate regions of Brazil and an ecological study of its causes. BMC Cancer. 2019;19:940. https://doi.org/10.1186/s12885-019-6184-1
GBD 2015 Mortality and Causes of Death Collaborators. Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1459-544. https://doi.org/10.1016/S0140-6736(16)31012-1
Ishitani LH, Teixeira RA, Abreu DMX, Paixão LMMM, França EB. Qualidade da informação das estatísticas de mortalidade: códigos garbage declarados como causas
de morte em Belo Horizonte, 2011-2013. Rev Bras Epidemiol. 2017;20 Supl 1:34-45. https://doi.org/10.1590/1980-5497201700050004
Pan American Health Organization, Division of Health and Human Development, Program on Health Situation Analysis. Revisions of the International Classification of Diseases (ICD-9 and ICD10): impact on health statistics. Epidemiol Bull. 1996;17(2):1-5.
Mello-Jorge MHP, Laurenti R, Gotlieb SLD. Análise da qualidade das estatísticas vitais brasileiras: a experiência de implantação do SIM e do SINASC. Cienc Saude Coletiva. 2007;12(3):643-54. https://doi.org/10.1590/S1413-81232007000300014
Lima EEC, Queiroz BL. Evolution of the deaths registry system in Brazil: associations with changes in the mortality profile, under-registration of death counts, and ill-defined causes of death. Cad Saude Publica. 2014;30(8):1721-30. https://doi.org/10.1590/0102-311X00131113
Almeida WS, Szwarcwald CL. Adequação das informações de mortalidade e correção dos óbitos informados a partir da Pesquisa de Busca Ativa. Cienc Saude Coletiva. 2017;22(10):3193-203. https://doi.org/10.1590/1413-812320172210.12002016
Bray F, Jemal A, Torre LA, Forman D, Vineis P. Long-term realism and cost-effectiveness: primary prevention in combatting cancer and associated inequalities worldwide. J Natl Cancer Inst. 2015;107(12):djv273. https://doi.org/10.1093/jnci/djv273
Vasconcelos AMN, Gomes MMF. Transição demográfica: a experiência brasileira. Epidemiol Serv Saude. 2012;21(4):539-48. https://doi.org/10.5123/S1679-49742012000400003
Machado CV, Azevedo e Silva G. Political struggles for a universal health system in Brazil: successes and limits in the reduction of inequalities. Global Health. 2019;15 Suppl 1:77. https://doi.org/10.1186/s12992-019-0523-5
Hone T, Mirelman AJ, Rasella D, Paes-Sousa R, Barreto ML, Rocha R, et al. Effect of economic recession and impact of health and social protection expenditures on
adult mortality: a longitudinal analysis of 5565 Brazilian municipalities. Lancet Glob Health. 2019;7(11):e1575-83. https://doi.org/10.1016/S2214-109X(19)30409-7
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