Coexistence of HIV-1 variants with dipeptidic insertion in the reverse transcriptase gene

Authors

  • Aline Aki Tanikawa Universidade Estadual Paulista; Faculdade de Medicina de Botucatu; Laboratorio de Biologia Molecular
  • Sarita Fiorelli Dias Barreto Universidade Estadual Paulista; Faculdade de Medicina de Botucatu; Laboratorio de Biologia Molecular
  • Rejane Maria Tommasini Grotto Universidade Estadual Paulista; Faculdade de Medicina de Botucatu; Laboratorio de Biologia Molecular
  • Maria Ines de Moura Campos Pardini Universidade Estadual Paulista; Faculdade de Medicina de Botucatu; Laboratorio de Biologia Molecular

DOI:

https://doi.org/10.1590/rsp.v47i4.76615

Abstract

The aim of this communication was to describe the detection of the coexistence of HIV-1 variant with dipeptide insertion between codons 69 and 70 of reverse transcriptase. These variants were isolated from a 16-year-old male patient, undergoing treatment in the city of Marilia, SP, Southeastern Brazil. After confirmation of treatment failure, resistance to antiretroviral drugs testing was performed and two variants with the insertions of the aminoacids Ser-Gly/Ser-Ala at codon 69 of reverse transcriptase were detected, besides the T69S mutation. These insertions have low prevalence, have not been reported in situations of coexistence in Brazil and are related to multidrug resistance, which makes this epidemiological finding relevant.

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Published

2013-08-01

Issue

Vol. 47 No. 4 (2013)

Section

Brief Communication

How to Cite

Tanikawa, A. A., Barreto, S. F. D., Grotto, R. M. T., & Pardini, M. I. de M. C. (2013). Coexistence of HIV-1 variants with dipeptidic insertion in the reverse transcriptase gene. Revista De Saúde Pública, 47(4), 821-823. https://doi.org/10.1590/rsp.v47i4.76615