Use of mutagenicity tests to assess occupational exposure

Authors

  • Ana Gabriela da Silva Kohatsu Faculdade de Medicina da Universidade de São Paulo FM/USP.
  • Fernanda Shimabukuro Faculdade de Medicina da Universidade de São Paulo FM/USP.

DOI:

https://doi.org/10.11606/issn.2317-2770.v12i1-2p15-21

Keywords:

Cytogenetics. Mutagenicity tests. Micronucleus tests. Occupational exposure. Occupational health, bus driver.

Abstract

The cytogenetic tests are important biomarkers of exposure to evaluate mutagenic effects of external agents and its metabolites in the internal cell environment. These tests have been used in the biological monitoring of populations exposed to genotoxic substances, mainly in the occupational area. The frequency micronucleous, evaluated in 24 bus drivers of the city of São Paulo, was higher than the frequency observed in a control group of 13 bus drivers who were away from their jobs for more than six months. In spite of the low number of individuals, the partial results of this research that was performed with patients who attended the Occupational Health Service of the HCFMUSP, suggest an expansion of this project to evaluate a possible inclusion of periodic tests protocol for these professionals in the future.

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Author Biographies

  • Ana Gabriela da Silva Kohatsu, Faculdade de Medicina da Universidade de São Paulo FM/USP.
    Bióloga, Aprimoranda em Saúde e Trabalho pelo Serviço de Saúde Ocupacional do Hospital das Clínicas da
    Faculdade de Medicina da Universidade de São Paulo FM/USP.
  • Fernanda Shimabukuro, Faculdade de Medicina da Universidade de São Paulo FM/USP.

    Biomédica, Mestranda de Fisiopatologia Experimental - Departamento de Medicina Legal, Ética Médica e Medicina Social e do Trabalho da Faculdade de Medicina da Universidade de São Paulo FM/USP - Laboratório de Imunohematologia e Hematologia Forense (LIM/40).

References

Published

2007-11-07

Issue

Section

Contents

How to Cite

1.
Kohatsu AG da S, Shimabukuro F. Use of mutagenicity tests to assess occupational exposure. Saúde ética justiça [Internet]. 2007 Nov. 7 [cited 2026 Mar. 10];12(1-2):15-21. Available from: https://revistas.usp.br/sej/article/view/44355