Has the introduction of genetic techniques in medicine occasioned an anthropological rupture?
DOI:
https://doi.org/10.1590/S1678-31662004000200002Keywords:
Anthropological rupture, Genetization, Bioethics, Medical ethics, Medical genetics, BiotechnologyAbstract
In this article, a set of theoretical positions concerning the application of genetics in medicine is expounded and discussed, with the aim of examining a possible anthropological rupture. A thesis is defended about the dehumanization of medicine which arises as a consequence of the implementation of biotechnological procedures that aim at preventing and treating diseases associated to genetic phenomena and to human reproduction. According to this view, the "genetization" of medicine comes together with an ideology which should be denounced for challenging human dignity and liberty. After a critical examination of the actual impact of genetics in medicine, concrete cases of medical applications of genomics are analised in which contrary and favourable positions to the thesis of the dehumanizing character of genetization are compared.Downloads
References
Alwan, A. & Modell, B. Recommendations for introducing genetics services in developing countries. Nature Reviews Genetics, 4, p. 61, 2003.
American Society for Reproductive Medicine. Does ICSI carry inherent genetic risks? Birmingham, ASRM, 2000.
Barritt, J. A. et al. Spontaneous and artificial changes in human ooplasmic mitochondria. Human Reproduction, 15, p. 207-17, 2000. Suplemento especial 2.
Barritt, J. A. et al. Mitochondria in human offspring derived from ooplasmic transplantation. Human Reproduction, 16, 3, p. 513-6, 2001.
Bell, J. I. The double helix in medical practice. Nature, 421, p. 414-6, 2003.
Chain, E.; Florey, H. W. et al. Further observations on penicillin. The Lancet, 238, 6155, p. 177-89, 1941.
Cohen, J. et al. Ooplastic transfer in mature human oocytes. Molecular Human Reproduction, 4, p. 269-80, 1998.
Condit, C. & Williams, M. Audience responses to the discourse of medical genetics: evidence against the critique of medicalization. Health Communication, 9, 3, p. 219-35, 1997.
Debru, C. & Nouvel, P. Le possible et les biotechnologies. Paris, PUF, 2003.
Delay, J. & Deniker, P. Trente-huit cas des psychoses traitées par la cure prolongée et continue de 4560 RP. Compte Rendus du Congres Alien Neurol France, 50, p. 503-13, 1952.
Doll, R. & Hill, A. B. et al. Smoking and carcinoma of the lung: preliminary report. British Medical Journal, 2, p. 739-48, 1950.
Feldman, D. & Tauber, A. Sickle cell anemia: reexamining the first “molecular disease”. Bulletin of the History of Medicine, 71, 4, p. 623-50, 1997.
Fugger, E. F. et al. Birth of normal daughters after microsort sperm separation and intrauterine insemination, in vitro fertalization, or intracytoplasmic sperm injection. Human Reproduction, 13, p. 2367-70, 1998.
Gordon, J. W. Genetic enhancement in humans. Science, 283, p. 2023-4, 1999.
Habermas, J. L’avenir de la nature humaine. Vers un eugenisme liberal? Trad. de C. Bouchindhomme. Paris, Gallimard, 2002.
Hansen, M. et al. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. New England Journal of Medicine, 346, 10, p. 725-30, 2002.
Have, H. ten. Genetics and culture: the geneticization thesis. Medicine, Health Care and Philosophy, 4, 3, p. 295-304, 2001.
Hedgecoe, A. M. Geneticization, medicalisation and polemics. Medicine, Health Care and Philosophy, 1, 3, 1998.
_______. Ethical boundary work: geneticization, philosophy and the social sciences. Medicine, Health Care and Philosophy, 4, 3, p. 305-9, 2001.
Hoedemaekers, R. & Have, H. ten. Geneticization: the Cyprus paradigm. Journal of Medicine and Philosophy, 23 , 4, p. 274-87, 1998.
Holtzman, N. A. & Marteau, T. M. Will genetics revolutionise medicine? New England Journal of Medicine, 343, p. 141-4, 2000.
Husserl, E. La crise des sciences européennes et la phénoménologie transcendentale. Trad. de G. Granel, Paris, Gallimard, 1962.
Hwang, W. S. et al. Science, 12 fev., 2004. Disponível online.
Illich, I. Limits to medicin. Medical nemesis: the expropriation of health. Nova Iorque, Harmonsdsworth/Penguin, 1977.
International Molecular Genetics Study of Autism Consortium. A full genome screen for autism with evidence for linkage to a region on chromosome 7q’. Human Molecular Genetics, 7, 3, p. 571-8, 1998.
Laborit, H., Huguenard, P. & Alluaume, R. Un nouveau stabilisateur végétatif, le 4560 RP. Presse Médicale, 60, p. 206-8, 1952.
Leboyer, M. & Bellivier, F. Psychiatric genetics. Methods and reviews. Totowa/Nova Jersey, Human Press, 2003.
Le Breton, D. La chair à vif. Usages médicaux et mondains du corps humain. Paris, Métaillé, 1993.
Lippman, A. Prenatal genetics testing and screening: constructing neds and reinforcing inequalites. American Journal of Law and Medicine, 17, 1-2, p. 15-50, 1991.
Morange, M. La part des genes. Paris, O. Jacob, 1998.
Nelkin, D. & Lindee, M. S. The DNA mystique: the gene as a cultural icon. Nova Iorque, Freeman, 1995.
Organisation Mondiale de la Santé/World Heath Organization. Rapport sur la santé dans le monde 2001.
La santé mentale: nouvelle conception, noveaux espoirs. Genebra, OMS, 2001. Disponível em:
Pauling, L. et al. Sickle cell anemia, a molecular disease. Science, 110, p. 543-8, 1949.
Parens, E. & Knowles, L. P. Reprogenetics and public policy. Reflections and recommendations. Hastings Center Report, 33, 4, p. S1-S24, jul.-aug. 2003. Suplemento especial.
Ramanawamy, S. et al. A molecular signature of metastasis in primary solid tumors. Nature Genetics, 36, p. 38-44, 2003.
Rostand, J. Uchronie scientifique. La biologie et l’avenir humain. Paris, Albin Michel, 1950.
Stéphane, J. et al. Mutations of the X-linked genes encodage neuroligins NLGN and NLGN4 are associated with autism. Nature Genetics, maio 2003. Disponível em: <http://www.nature.com/ng/>
Templeton, A. Ooplasmic transfer: proceed with care. New England Journal of Medicine, 346, p. 773-5, 2002.
Vassal, G. La signature génétique au service da la thérapie. L’identification de profils d’expression de gènes associes au pronostic devrait permettre, à l’avenir, d’adapter la prise em charge au risque de chaque patient dans le domaine de la cancérologie. Concours Medical, 125, 25, p. 1422-4, 10 sept. 2003.
Entrevista.
Verlinsky, Y. et al. Preimplantation diagnosis for Franconi anemia combined with HLC matching. Journal of the American Medical Association, 285, p. 3130-3, 2001.
Vijver, M. Van de. et al. A gene expression signature as a predictor of survival in breast cancer. New England Journal of Medicine, 347, p. 1999-2009, 2002.
World Federation of Neurology: Research Committee, Research Group on Huntington’s Chorea. Ethical issues policy statement on Huntington´s disease molecular genetics predicitive test. Journal of the Neurological Sciences, 94, p. 327-32, 1989.
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