Biochemical evaluation of the cerebrospinal fluid from clinically normal dogs and from young dogs with distemper enchephalitis

Abstract

Cerebrospinal fluid samples were obtained from 20 normal dogs and from 20 dogs with canine distemper encephalitis, for biochemical evaluation. Blood samples were taken simultaneously and the values of chlorides, glucose, creatine phosphokinase and glutamic oxaloacetic transaminase were determined to verify if there is any correlation between those constituents from blood and from cerebrospinal fluid. Biochemical evaluation of the cerebrospinal fluid from normal dogs were: glucose concentration: 86,09 ± 17,76 mg/dl, chloride levels: 117,36 ± 21,35 mEq/L, creatine phosphokinase levels: 3.77 ± 1.72 Ul/L and glutamic oxaloacetic levels: 7.43 ± 4.61 Ul/L. Biochemical evaluation of the cerebrospinal fluid from dogs with distemper encephalitis were: glucose concentration: 88.85 ± 14.82 mg/dl, chloride levels: 118.67 ± 12.82 mEq/L, creatine phosphokinase levels: 26.38 ± 29.27 Ul/L and glutamic oxaloacetic levels: 65.70 ± 23.72 Ul/L. Chloride, creatine phosphokinase and glutamic oxaloacetic seric levels and glucose plasmatic concentration in normal dogs and in dogs with distemper encephalitis were, respectively, 103.43 ± 16.00 and 103.43 ±11,99 mEq/L, 95.75 ± 22.83 and 272.50 ± 140.95 Ul/L, 23.77 ± 5.20 and 23.44 ± 4.81 Ul/L, 119.12 ± 21.46 and 106.12 ± 17.73 mg/dl. There was a positive correlation between the glucose plasmatic concentration and the glucose concentration in cerebrospinal fluid in normal dogs and in dogs with distemper encephalitis, and between creatine phosphokinase levels in cerebrospinal fluid and seric levels in dogs with distemper. There were no differences between chloride seric level and chloride in cerebrospinal fluid in normal dogs and in dogs with distemper. CPK and GOT levels in cerebrospinal fluid from dogs with distemper encephalitis were higher than in normal dogs.