Anátomo histopathologic evaluation of the effect of medroxiprogesterone acetate and megestrol acetate on the uterus of adult bitches

Abstract

In this trial, 18 adult clinically sound bitches, without clinical symptoms of estrus were utilized, being randomly assigned in 6 groups with 3 animals each. After uterine biopsy for control, medroxiprogesterone acetate was injected into females of the group I, II and III, and megestrol acetate into females of the group IV, V and VI. It was observed that both drugs were capable in inducing endometritis, but this effect was more discrete in the animals of group IV, V and VI. The occurrence of poliuria, polidipsia, abdominal distention, purulent or bloody vaginal secretion, leucocitosis or anemia was not recorded.