Influence of BCG inespecific stimulation on the hamsters susceptibility to the experimentai infection L. interrogans serovar pomona

Authors

  • Clebert José Alves Universidade Federal da Paraíba
  • Silvio Arruda Vasconcellos Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Claudio Roberto de Almeida Camargo Instituto Butantan, São Paulo, SP
  • Nicodemos Alves de Macedo Universidade Federal do Piauí
  • Zenaide Maria de Morais Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Rodolfo Nürmberger Junior Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • Sonia Regin Pinheiro Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP
  • José Soares Ferreira Neto Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, São Paulo, SP

DOI:

https://doi.org/10.11606/issn.1678-4456.bjvras.1992.51984

Keywords:

Leptospirosis, Leptospira interrogans, BCG

Abstract

The influence of BCG on the resistance of hamsters experimentally infected with Leptospira interrogans serovar pomona was investigated. Forty-eight young male hamsters were used as the follow: 23 of them have administered two intraperitoneal dosis of BCG with seven days of interval: the remaining 25 were treated with placebo (Souton solution) in the same way as in the BCG treatment. On the third day after the second BCG or placebo administration, each animal was inoculated with 0.5 ml of a suspension of L. pomona through the intraperitoneal route. The animals were observed for signs and symptoms of leptospirosis during a period of 21 days and those in the agonic state of disease were killed and their kidney and serum samples were taken for the demonstration of antibodies and leptospiroses, by means of serum agglutination test and by the direct culture of kidney fragments. All of the survivors were killed at the 21st day post infection and evaluated for antibodies an leptospires, as described above. For the BCG treated group, no death was recorded (0/23 or 0,00%) whereas in the control group 80% of deaths (20/25) were observed.

Downloads

Downloads

Published

1992-12-02

Issue

Vol. 29 No. 2 (1992)

Section

PREVENTIVE VETERINARY MEDICINE

License

The journal content is authorized under the Creative Commons  BY-NC-SA  license (summary of the license: https://creativecommons.org/licenses/by-nc-sa/4.0 | full text of the license: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode) 

How to Cite

1.
Alves CJ, Vasconcellos SA, Camargo CR de A, Macedo NA de, Morais ZM de, Nürmberger Junior R, et al. Influence of BCG inespecific stimulation on the hamsters susceptibility to the experimentai infection L. interrogans serovar pomona. Braz. J. Vet. Res. Anim. Sci. [Internet]. 1992 Dec. 2 [cited 2025 Mar. 2];29(2):193-9. Available from: https://revistas.usp.br/bjvras/article/view/51984