Investigação dos efeitos do exercício terapêutico sobre a regeneração nervosa periférica
DOI:
https://doi.org/10.11606/issn.2317-0190.v17i4a103378Palavras-chave:
Sistema Nervoso Periférico, Regeneração Nervosa, Exercício, Ratos WistarResumo
O sistema nervoso periférico apresenta relativa capacidade de rege- neração após uma lesão. Após a axonotmese o nervo ciático produz respostas morfo-funcionais, no músculo alvo, no epicentro da lesão e alguns distritos neuronais retrógrados. Apesar dos avanços terapêuti- cos, a restauração funcional é incompleta na maioria dos casos. Neste contexto, nós testamos se o exercício (nado) é capaz de interferir na marcha funcional e reações de plasticidade nos motoneurônios da medula espinhal. Quarenta ratos foram divididos em quatro grupos (n=10 cada), submetidos a 30 min/dia de nado, iniciando no 1, 7, 14, 21 dias após lesão do nervo ciático. Todos os grupos apresentaram recuperação funcional, não observamos diferenças significantes nos números de motoneurônios da medula espinhal entre os diferentes grupos estudados. De acordo com a análise funcional e histológica, o exercício terapêutico, nas condições do presente estudo, foi incapaz de acelerar o processo regenerativo.
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