Testosterone and ischemic stroke
DOI:
https://doi.org/10.11606/issn.2317-0190.v25i3a162587Keywords:
Stroke, Androgens, Testosterone, RehabilitationAbstract
Serum testosterone levels have already been related to endothelial function, vascular aging and hemathological factors, possibly contributing to thrombus formation. As aging progresses, epidemiological data shows declining testosterone levels, impaired vascular function and an increasing incidence of vascular diseases like stroke. Objective: The aim of present paper is to describe studies with a possible relation of testosterone levels with stroke prevention, clinical presentation, and prognosis. Methods: A research and selection of articles, filtering for humans studies only, was conducted in three different eletronic scientific databases, (MEDLINE, SCIELO, LILACS), using related and registered terms (english and portuguese) about "stroke" and "testosterone". Only studies that encompasses the role of testosterone in stroke and its different clinical aspects were included in the present review. Results: The search retrieved 12 relevant studies for analysis and discussion relating testosterone and stroke (7 observational, 3 cross sectional, 2 experimental). Observational studies verified a preventive role of testosterone levels on stroke incidence, cross-sectional studies verified endocrinologial alterations like hypogonadism on acute stroke phase and better clinical presentation (severity, brain lesion size). Experimental controled studies observed clinical benefits of testosterone supplementation in rehabilitation patients. Conclusion: Despite the potential benefits of higher levels of testosterne in stroke spectrum, more studies that systematically aproach the role of testosterone in stroke prevention, severity, clinical features, prognosis, rehabilitation and mortality will be welcome to better elaborate future medical management and otimization in stroke spectrum.
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