Clinical and histopathological findings of a rare sinonasal glomangiopericytoma

Zahraa Noureddine El Moussaoui; Zahraa Al Najjar; Nada Diab; Zahraa Saker; Hassane Choukr; Ahmad K Aoude; Marwan Saliba; Bilal Shoumar; Mohamad Reda Noureddine El Moussaoui

Authors

Zahraa Noureddine El Moussaoui Lebanese University, Faculty of Medical Sciences, Neurology Department, Beirut, Lebanon https://orcid.org/0000-0002-5479-3021
Zahraa Al Najjar Al-Rassoul Al-Aazam Hospital, Pathology Department, Beirut, Lebanon https://orcid.org/0000-0002-0850-9093
Nada Diab Al-Rassoul Al-Aazam Hospital, Radiology Department, Beirut, Lebanon https://orcid.org/0000-0002-2383-955X
Zahraa Saker Lebanese University, Faculty of Medical Sciences, Neuroscience Research Center, Beirut, Lebanon https://orcid.org/0000-0003-0639-4277
Hassane Choukr Al-Rassoul Al-Aazam Hospital, Otolaryngology-Head and Neck Surgery Department, Beirut, Lebanon https://orcid.org/0000-0002-2150-3278
Ahmad K Aoude Al-Rassoul Al-Aazam Hospital, Neurosurgery Department, Beirut, Lebanon https://orcid.org/0000-0002-2062-9274
Marwan Saliba Al-Rassoul Al-Aazam Hospital, Pathology Department, Beirut, Lebanon https://orcid.org/0000-0001-9885-3930
Bilal Shoumar Al-Rassoul Al-Aazam Hospital, Radiology Department, Beirut, Lebanon https://orcid.org/0000-0002-6345-5614
Mohamad Reda Noureddine El Moussaoui Al-Rassoul Al-Aazam Hospital, Otolaryngology-Head and Neck Surgery Department, Beirut, Lebanon https://orcid.org/0000-0002-7589-5844

Keywords:

Epistaxis, Nasal Cavity, Paranasal Cavity, Paranasal Sinuses

Abstract

Glomangiopericytoma is a rare vascular neoplasm of the nasal cavity and paranasal sinuses that occurs during the sixth or seventh decade of life. It is categorized as a borderline tumor with low malignant potential and classified as a distinct entity of sinonasal tumors with perivascular myoid phenotype by the World Health Organization (WHO). We report the case of a 50-year-old woman with nasal obstruction and severe epistaxis. The nasal sinuses computed tomography (CT), and magnetic resonance imaging (MRI) demonstrated a 3.1 cm soft tissue mass occupying the upper part of the left nasal cavity invading the left paranasal sinuses and nasal septum, and the left eye medial rectus muscle. A total mass resection was performed by nasal endoscopy. The histological and immunohistochemical examination yielded the diagnosis of glomangiopericytoma. This case report aims to contribute to the knowledge of nasal neoplasms. The need for more data on this entity is the main obstacle to developing standardized treatment guidelines.

Downloads

Download data is not yet available.

References

Tse LL, Chan JK. Sinonasal haemangiopericytoma-like tumour: a sinonasal glomus tumour or a haemangiopericytoma? Histopathology. 2002;40(6):510-7. http://dx.doi.org/10.1046/j.1365-2559.2002.01396.x. PMid:12047761.

Thompson LD, Miettinen M, Wenig BM. Sinonasal-type hemangiopericytoma: a clinicopathologic and immunophenotypic analysis of 104 cases showing perivascular myoid differentiation. Am J Surg Pathol. 2003;27(6):737-49. http://dx.doi.org/10.1097/00000478-200306000-00004. PMid:12766577.

Stelow EB, Bishop JA. Update from the 4th edition of the World Health Organization classification of head and neck tumours: tumors of the nasal cavity, paranasal sinuses and skull base. Head Neck Pathol. 2017;11(1):3-15. http://dx.doi.org/10.1007/s12105-017-0791-4. PMid:28247233.

Gökdoğan O, Demirhan B, Köybaşıoğlu A, İleri F. An unusual mass of nasal cavity: recurrent glomangiopericytoma. Kulak Burun Bogaz Ihtis Derg. 2015;25(4):240-4. http://dx.doi.org/10.5606/kbbihtisas.2015.43433. PMid:26211867.

Angouridakis N, Zaraboukas T, Vital J, Vital V. Sinonasal hemangiopericytoma of the middle turbinate: a case report and brief review of the literature. B-ENT. 2007;3(3):139-43. PMid:17970438.

Ghaloo SK, Dhanani R, Pasha HA, Wasif M, Fatima S, Ikram M. Glomangiopericytoma: a rare tumour of sinonasal cavity. J Pak Med Assoc. 2020;70(12B):2469-71. PMid:33475567.

Zielińska-Kaźmierska B, Grodecka J, Teodorczyk-Werfel D, Milcarz R. The midfacial glomangiopericytoma - case report. J Oral Biol Craniofac Res. 2015;5(2):124-6. http://dx.doi.org/10.1016/j.jobcr.2015.02.003. PMid:26258028.

Al-Shaar HA, Macdonald KI, Labib MA. Glomangiopericytoma simulating an intracavernous meningioma. Surg Neurol Int. 2016;7(Suppl 5):S142-7. http://dx.doi.org/10.4103/2152-7806.177888. PMid:27069746.

Bignami M, Dallan I, Battaglia P, Lenzi R, Pistochini A, Castelnuovo P. Endoscopic, endonasal management of sinonasal haemangiopericytoma: 12-year experience. J Laryngol Otol. 2010;124(11):1178-82. http://dx.doi.org/10.1017/S0022215110000952. PMid:20438660.

Stout AP, Murray MR. Hemangiopericytoma: a vascular tumor featuring Zimmermann's pericytes. Ann Surg. 1942;116(1):26-33. http://dx.doi.org/10.1097/00000658-194207000-00004. PMid:17858068.

Compagno J, Hyams VJ. Hemangiopericytoma-like intranasal tumors. A clinicopathologic study of 23 cases. Am J Clin Pathol. 1976;66(4):672-83. http://dx.doi.org/10.1093/ajcp/66.4.672. PMid:970369.

Granter SR, Badizadegan K, Fletcher CD. Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: a spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol. 1998;22(5):513-25. http://dx.doi.org/10.1097/00000478-199805000-00001. PMid:9591720.

Chaouki A, Najib Z, Mkhatri A, Rouadi S, Mahtar M. Glomangiopericytoma of the inferior nasal turbinate: a case report. Int J Surg Case Rep. 2021;79:409-12. http://dx.doi.org/10.1016/j.ijscr.2021.01.051. PMid:33517215.

Pavelić K, Cabrijan T, Hrasćan R, et al. Molecular pathology of hemangiopericytomas accompanied by severe hypoglycemia: oncogenes, tumor-suppressor genes and the insulin-like growth factor family. J Cancer Res Clin Oncol. 1998;124(6):307-14. http://dx.doi.org/10.1007/s004320050174. PMid:9692837.

Catalano PJ, Brandwein M, Shah DK, Urken ML, Lawson W, Biller HF. Sinonasal hemangiopericytomas: a clinicopathologic and immunohistochemical study of seven cases. Head Neck. 1996;18(1):42-53. http://dx.doi.org/10.1002/(SICI)1097-0347(199601/02)18:1<42::AID-HED6>3.0.CO;2-Z. PMid:8774921.

Chihani M, Aljalil A, Touati M, et al. Glomangiopericytoma: an uncommon sinonasal perivascular tumor with particular characteristics. Egypt J Ear Nose Throat Allied Sci. 2011;12(3):167-70. http://dx.doi.org/10.1016/j.ejenta.2012.01.001.

Psoma E, Karkos PD, Dova S, et al. Sinonasal glomangiopericytoma treated with preoperative embolisation and endoscopic sinus surgery. Ecancermedicalscience. 2016;10:692. http://dx.doi.org/10.3332/ecancer.2016.692. PMid:27994648.

Suh CH, Lee JH, Lee MK, et al. CT and MRI findings of glomangiopericytoma in the head and neck: case series study and systematic review. AJNR Am J Neuroradiol. 2020;41(1):155-9. http://dx.doi.org/10.3174/ajnr.A6336. PMid:31806599.

Abdelaal TM. Clinical and histopathological study of a rare sinonasal glomangiopericytoma: a case report. Egypt J Otolaryngol. 2018;34(4):345-50. http://dx.doi.org/10.4103/ejo.ejo_41_18.

Duval M, Hwang E, Kilty SJ. Systematic review of treatment and prognosis of sinonasal hemangiopericytoma. Head Neck. 2013;35(8):1205-10. http://dx.doi.org/10.1002/hed.23074. PMid:22733718.

Lasota J, Felisiak-Golabek A, Aly FZ, Wang ZF, Thompson LD, Miettinen M. Nuclear expression and gain-of-function β-catenin mutation in glomangiopericytoma (sinonasal-type hemangiopericytoma): insight into pathogenesis and a diagnostic marker. Mod Pathol. 2015;28(5):715-20. http://dx.doi.org/10.1038/modpathol.2014.161. PMid:25431235.

Higashi K, Nakaya K, Watanabe M, et al. Glomangiopericytoma of the nasal cavity. Auris Nasus Larynx. 2011;38(3):415-7. http://dx.doi.org/10.1016/j.anl.2010.08.009. PMid:21093999.

Al-Jobory YM, Pan Z, Manes RP, Omay SB, Ikuta I. Sinonasal glomangiopericytoma: review of imaging appearance and clinical management update for a rare sinonasal neoplasm. Yale J Biol Med. 2021;94(4):593-7. PMid:34970096.

Clinical and histopathological findings of a rare sinonasal glomangiopericytoma

Authors

Keywords:

Abstract

Downloads

References

Downloads

Published

Issue

Section

License

Copyright

How to Cite

Keywords

Language