Robustness evaluation of the chromatographic method for the quantitation of lumefantrine using Youden's test

Authors

  • Isabela da Costa César Federal University of Minas Gerais; Faculty of Pharmacy; Department of Pharmaceutical Products
  • Gerson Antônio Pianetti Federal University of Minas Gerais; Faculty of Pharmacy; Department of Pharmaceutical Products

DOI:

https://doi.org/10.1590/S1984-82502009000200007

Keywords:

Lumefantrine^i1^sdeterminat, Youden's test, High Performance Liquid Chromatography^i1^squantitative analy

Abstract

Youden's test is a reliable method to evaluate the robustness of analytical methods, by means of an experiment design which involves seven analytical parameters combined in eight tests. In the present study, we assessed the robustness of a chromatographic method to quantify lumefantrine in raw material samples, using Youden's test. Hence, it was possible to determine the effect of each analytical parameter in the final analysis results. Youden's test showed to be a simple and feasible procedure to evaluate the robustness of chromatographic methods.

Downloads

Download data is not yet available.

Downloads

Published

2009-06-01

Issue

Vol. 45 No. 2 (2009)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

Robustness evaluation of the chromatographic method for the quantitation of lumefantrine using Youden’s test . (2009). Brazilian Journal of Pharmaceutical Sciences, 45(2), 235-240. https://doi.org/10.1590/S1984-82502009000200007