Development and in vitro evaluation of Letrozole loaded biodegradable nanoparticles for breast cancer therapy

Authors

  • Sanjoy Kumar Dey Jadavpur University; Department of Pharmaceutical Technology; Pharmaceutics Research Laboratory-II
  • Bivash Mandal Jadavpur University; Department of Pharmaceutical Technology; Pharmaceutics Research Laboratory-II
  • Manas Bhowmik Jadavpur University; Department of Pharmaceutical Technology; Pharmaceutics Research Laboratory-II
  • Lakshmi Kanta Ghosh Jadavpur University; Department of Pharmaceutical Technology; Pharmaceutics Research Laboratory-II

DOI:

https://doi.org/10.1590/S1984-82502009000300025

Keywords:

Breast cancer^i1^sther, Letrozole, Biodegradable nanoparticles

Abstract

The objectives of our study were to prepare and evaluate a biodegradable nanoparticulate system of Letrozole (LTZ) intended for breast cancer therapy. LTZ loaded poly(lactide-co-glycolide) nanoparticles (LTZ-PLGA-NPs) were prepared by emulsion-solvent evaporation method using methylene chloride and polyvinyl alcohol. Percentage of drug (with respect to polymer) was selected as formulation variable. LTZ-PLGA-NPs were characterized by particle size, zeta potential, infrared spectra, drug entrapment efficiency and in vitro release. Sonication was done with an ultrasound pulse sonicator at 70 W, 30 kHz for 90 sec to produce stable NPs of mean size range from 64 nm to 255 nm with high entrapment efficiency (68% to 82%). Percentage of drug significantly influenced particle size, entrapment efficiency and release (p <0.05). The system sustained release of LTZ significantly and further investigation could exhibit its potential usefulness in breast cancer therapy.

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Published

2009-09-01

Issue

Vol. 45 No. 3 (2009)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

Development and in vitro evaluation of Letrozole loaded biodegradable nanoparticles for breast cancer therapy . (2009). Brazilian Journal of Pharmaceutical Sciences, 45(3), 585-591. https://doi.org/10.1590/S1984-82502009000300025