Study of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine

Authors

  • Elthon Gomes Fernandes da Silva Federal University of Pernambuco; Center of Biologic Science; Anatomy Department
  • Alessandro Aires Alexandre Federal University of Pernambuco; Center of Biologic Science; Anatomy Department
  • Gerlane Karla Bezerra Oliveira Nascimento Federal University of Pernambuco; Center of Biologic Science; Anatomy Department
  • Jaciel Benedito de Oliveira Federal University of Pernambuco; Center of Biologic Science; Anatomy Department
  • Elizabeth da Silveira Neves Federal University of Pernambuco; Center of Biologic Science; Anatomy Department
  • Austregézilo Vieira da Costa Sobrinho Federal University of Pernambuco; Center of Biologic Science; Anatomy Department
  • Maria de Fátima Galdino da Silveira Federal University of Pernambuco; Center of Biologic Science; Anatomy Department

DOI:

https://doi.org/10.1590/S1984-82502009000400019

Keywords:

Caffeine^i1^seffe, Postnatal development, Central nervous system^i1^sstimula

Abstract

The influence of caffeine, administered to rats, on the somatic and sensory-motor development of the offspring was investigated. Female Wistar rats were divided into a control group and a treated group and received drinking water and a 0.1% solution of caffeine orally, respectively. The offspring, also divided into a control group and a treated group, received daily monitoring until the 20th day of life to verify alterations in somatic neural development. The offspring of the treated group had reduced weight on the day of birth and on the 1st, 5th, 15th and 20th days of life; shorter snout-anus length (evaluation done daily); shorter snout-tail length on the day of birth and on the 1st, 5th and 10th days of life, and signs of retardation of somatic and sensory-motor maturation. These results allowed the conclusion that administration of caffeine to rats affects somatic and sensory-motor development of offspring.

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Published

2009-12-01

Issue

Vol. 45 No. 4 (2009)

Section

Original Papers

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

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How to Cite

Study of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine . (2009). Brazilian Journal of Pharmaceutical Sciences, 45(4), 743-749. https://doi.org/10.1590/S1984-82502009000400019