Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation
DOI:
https://doi.org/10.1590/S1984-82502009000400021Keywords:
Animal experimentation^i1^salternative methods in vi, Experiments^i1^sin vitro meth, Corrositex®^i1^sin vitro method/experime, BCOP^i1^sin vitro method/experime, HET-CAM^i1^sin vitro method/experimeAbstract
Tests in animals are used as models in toxicological and investigative studies. However, such tests have been considered inhumane because they can cause pain and suffering to experimental animals, while these methods can often be subjective. Protests calling for animal protection have questioned the effectiveness of in vivo tests and suggest the introduction of alternative, in vitro methods. International organizations, such as the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), the National Institute of Health (NIH), the Organization for Economic Co-operation and Development (OECD), that regulate and develop new alternative animal models, have indicated the running of preliminary assays and execution of sequential tests, which consider physical-chemical properties and data of in vitro assays, before performing in vivo studies. Towards this background, the objective of the present article was to select promising alternative methods such as Corrositex®, BCOP and HET-CAM, intended to refine or replace the use of animals and reduce their suffering.Downloads
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Published
2009-12-01
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Original Papers
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How to Cite
Corrositex®, BCOP and HET-CAM as alternative methods to animal experimentation . (2009). Brazilian Journal of Pharmaceutical Sciences, 45(4), 759-766. https://doi.org/10.1590/S1984-82502009000400021