The effects of metformın, acetylsalıcylıc acıd and ıbuprofen on telomerase enzyme actıvıty: ınhıbıtory effect of ıbuprofen

Authors

  • Aykut Topal Burdur Mehmet Akif Ersoy University, Burdur, Turkey
  • Irem Alkan Burdur Mehmet Akif Ersoy University, Burdur, Turkey
  • Didem Korkmaz Burdur Mehmet Akif Ersoy University, Burdur, Turkey
  • Hulya Yildiz Burdur Mehmet Akif Ersoy University, Burdur, Turkey
  • Muazzez Tikirdik Suleyman Demirel University, Isparta, Turkey https://orcid.org/0000-0002-9245-5445
  • Ayse Gul Mutlu Burdur Mehmet Akif Ersoy University. Faculty of Science and Literature, Burdur, Turkey https://orcid.org/0000-0002-2037-6473

DOI:

https://doi.org/10.1590/s2175-97902022310233

Keywords:

Telomerase, Metformin, Ibuprofen, Acetylsalicylic acid, SOD, Catalase

Abstract

Telomerase enzyme is necessary for the elongation of telomeres while telomerase being critical for aging and cancer. Metformin, ibuprofen, and acetylsalicylic acid used in this research are drugs that millions of people already use and that many are likely to use in future. In this study, the effects of these drugs on telomerase activity of Mus musculus swiss albino mice in liver tissue were investigated and the telomerase activity was measured with a PCR-ELISA based kit. In the study a possible connection between telomerase enzyme activity and activities of antioxidant enzymes was also investigated by determining the activity of superoxide dismutase (SOD) and catalase enzymes. The data obtained show that metformin slightly decreased telomerase enzyme activity in low dose application; however, this change was not statistically significant. In ibuprofen application, there was a significant inhibitory effect when high doses were used; whereas, there was a slight inhibitory effect at low doses. In acetylsalicylic acid application, a slight activator effect was detected; it was not statistically significant, though. Metformin was observed to increase catalase and SOD activities in general while low and high doses of acetyl salicylic acid showed different effects. In addition, ibuprofen caused a statistically significant increase in liver SOD values. It is important to note that this study demonstrated a significant inhibitory effect of ibuprofen on telomerase enzyme activity in animal models.

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Published

2023-04-14

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Original Article

How to Cite

The effects of metformın, acetylsalıcylıc acıd and ıbuprofen on telomerase enzyme actıvıty: ınhıbıtory effect of ıbuprofen. (2023). Brazilian Journal of Pharmaceutical Sciences, 59, e21233. https://doi.org/10.1590/s2175-97902022310233

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