Applicability of [18F]FDG/PET for investigating rosmarinic acid preconditioning efficacy in a global stroke model in mice
DOI:
https://doi.org/10.1590/s2175-97902023e21555Keywords:
[18F]FDG, Positron Emission Tomography, SUV, SPM, Rosmarinic Acid, StrokeAbstract
Positron emission tomography (PET) is a non-invasive nuclear imaging technique that uses radiotracers to track cell activity. The radiopharmaceutical 18F-fluoro-2-deoxyglucose ([18F] FDG) is most commonly used in nuclear medicine for the diagnosis of various diseases, including stroke. A stroke is a serious condition with high mortality and morbidity rates. Rosmarinic acid (RA) is a promising therapeutic agent that exerts neuroprotective effects against various neurological diseases. Therefore, this study aimed to evaluate the applicability of [18F]FDG/PET for investigating the neuroprotective effects of RA in case of a global stroke model in mice. The [18F]FDG/PET technique facilitates the observation of ischemia and reperfusion injuries in the brain. Moreover, the recovery of glucose metabolism in three specific brain regions, the striatum, superior colliculus, and inferior colliculus, was observed after preconditioning with RA. It was concluded that the [18F]FDG/PET technique may be useful for stroke diagnosis and the assessment of treatment response. In addition, a long-term longitudinal study using biochemical analysis in conjunction with functional imaging may provide further conclusive results regarding the effect of RA on cerebral ischemia.
Downloads
References
Baron JC. Protecting the ischaemic penumbra as an adjunct to thrombectomy for acute stroke. Nat Rev Neurol 2018;14(6):325-37.
Cui H-Y, Zhang X-J, Yang Y, Zhang C, Zhu C-H, Miao J-Y, et al. Rosmarinic acid elicits neuroprotection in ischemic stroke via Nrf2 and heme oxygenase 1 signaling. Neural Regen Res 2018;13(12):2119-28.
Ferreira SZ, Silva JB, Waquil SS, Correia RF. Stability study of 2-[18F]fluoro-2-deoxy-D-glucose (18FDG) stored at room temperature by physicochemical and microbiological assays In: 2009 International Nuclear Atlantic Conference - INAC 2009. September 27 to October 2; Rio de Janeiro: Associação Brasileira de Energia Nuclear. Available from: https://www.severin.su/wp-content/uploads/2020/01/fdg-stability.pdf
» https://www.severin.su/wp-content/uploads/2020/01/fdg-stability.pdf
Fonteles AA, de Souza CM, de Sousa Neves JC, Menezes APF, Santos do Carmo MR, Fernandes FDP, et al. Rosmarinic acid prevents against memory deficits in ischemic mice. Behav Brain Res 2016;297:91-103.
Jaiswal S, Cramer N, Scott J, Meyer C, Xu X, Whiting K, et al. [18F] FDG PET to study the effect of simulated high altitude on regional brain activity in mice. J Nucl Med 2017;58(1):1246.
Kapoor V, McCook BM, Torok FS. An Introduction to PET-CT Imaging. RadioGraphics 2004;24(2):523-43.
Katan M, Luft A. Global health neurology. Semin Neurol 2018;38:208-11.
Lancelot S, Zimmer L. Small-animal positron emission tomography as a tool for neuropharmacology. Trends Pharmacol Sci 2010;31(9):411-7.
León-Moreno LC, Castañeda-Arellano R, Rivas-Carrillo JD, Dueñas-Jiménez SH. Challenges and improvements of developing an ischemia mouse model through bilateral common carotid artery occlusion. J Stroke Cerebrovasc Dis 2020;29(5):104773
Li Y, Zhang B, Yu K, Li C, Xie H, Bao W, et al. Effects of constraint-induced movement therapy on brain glucose metabolism in a rat model of cerebral ischemi: a micro PET/CT study. Int J Neurosci 2018; Aug;128(8):736-745.
Luan H, Kan Z, Xu Y, Lv C, Jiang W. Rosmarinic acid protects against experimental diabetes with cerebral ischemia: Relation to inflammation response. J Neuroinflammation 2013; Feb 17;10:28. Nasrallah I, Dubroff J. An overview of PET neuroimaging. Semin Nucl Med 2013;43(6):449-61.
Phelps ME, Hoffman EJ, Mullani NA, Ter-Pogossian MM. Application of annihilation coincidence detection to transaxial reconstruction tomography. J Nucl Med 1975;16(3):210-24.
Ramalho LNZ, Pasta ÂAC, Terra VA, Augusto MJ, Sanches SC, Souza-Neto FP, et al. Rosmarinic acid attenuates hepatic ischemia and reperfusion injury in rats. Food Chem Toxicol 2014;74:270-8.
Rodrigo R, Fernández-Gajardo R, Gutiérrez R, Matamala JM, Carrasco R, Miranda-Merchak A, et al. Oxidative stress and pathophysiology of ischemic stroke: novel therapeutic opportunities. CNS Neurol Disord - Drug Targets 2013;12(5):698-714.
Silva BC, Miranda AS de, Rodrigues FG, Silveira ALM, Resende GH de S, Moraes MFD, et al. The 5-lipoxygenase (5-LOX) inhibitor zileuton reduces inflammation and infarct size with improvement in neurological outcome following cerebral ischemia. Curr Neurovasc Res 2015;12(4):398-403.
Singh V, Krishan P, Shri R. Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice. Metab Brain Dis 2018;33(4):1111-20.
Svoboda J, Litvinec A, Kala D, Pošusta A, Vávrová L, Jiruška P, et al. Strain differences in intraluminal thread model of middle cerebral artery occlusion in rats. Physiol Res 2019;68(1):37-48.
Toscano EC de B, Silva BC, Victoria ECG, Cardoso AC de S, Miranda AS de, Sugimoto MA, et al. Platelet-activating factor receptor (PAFR) plays a crucial role in experimental global cerebral ischemia and reperfusion. Brain Res Bull 2016;124:55-61.
Vaquero JJ, Kinahan P. Positron emission tomography: Current challenges and opportunities for technological advances in clinical and preclinical imaging systems. Annu Rev Biomed Eng 2015;17(1):385-414.
Zhang M, Yan H, Li S, Yang J. Rosmarinic acid protects rat hippocampal neurons from cerebral ischemia/reperfusion injury via the Akt/JNK3/caspase-3 signaling pathway. Brain Res 2017;1657:9-15.
Zhuang H, Codreanu I. Growing applications of FDG PET-CT imaging in non-oncologic conditions. J Biomed Res 2015;29(3):189-202.
Downloads
Published
Issue
Section
License
Copyright (c) 2023 Brazilian Journal of Pharmaceutical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.
The on-line journal has open and free access.