Development and evaluation of wafer loaded with sertaconazole solid dispersion for the treatment of oral candidiasis

Authors

  • Horieh Hajhashemi Isfahan University of Medical Sciences. School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan, Iran
  • Somayeh Taymouri Isfahan University of Medical Sciences. School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan, Iran https://orcid.org/0000-0001-6089-8367
  • Fatemeh Shafiee Isfahan University of Medical Sciences. School of Pharmacy and Pharmaceutical Sciences, Isfahan, Iran

DOI:

https://doi.org/10.1590/s2175-97902023e22452

Keywords:

Wafer, Solid dispersion, Sertaconazole, Oral candidiasis, Saturation solubility, Dissolution efficiency

Abstract

Candidiasis is one of the most common fungal infections of oral cavity in humans, causing great oral discomfort, pain and aversion to food. To develop more effective antifungal systems for the treatment of oral candidiasis, an oral mucoadhesive wafer containing sertaconazole solid dispersion (STZ-SD) was developed in this study. Dispersion of STZ in Soluplus® as a solubility enhancement excipient was done by melting, solvent evaporation and freeze drying method at various STZ to Soluplus® ratios. The optimized STZ-SD was then incorporated in the sodium carboxymethyl cellulose (SCMC) gel, xanthan gum gel, or their combination to prepare the lyophilized wafers. The swelling capacity, porosity, and mechanical, release and mucoadhesive properties of the wafers, together with their antifungal activity, were then evaluated. The melting method sample with the ratio of 8:1 showed the best results in terms of saturation solubility and dissolution rate. The STZ-SD-composite wafer exhibited higher hardness and mucoadhesion, as compared to those made of the SCMC polymer. The STZ-SD-wafer also exhibited a greater antifungal effect when compared to the STZ-wafer. The present study, thus, suggested that the STZ-SD-wafer could serve as a novel effective delivery system for oral candidiasis treatment.

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Published

2023-05-22

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Original Article

How to Cite

Development and evaluation of wafer loaded with sertaconazole solid dispersion for the treatment of oral candidiasis. (2023). Brazilian Journal of Pharmaceutical Sciences, 59, e22452. https://doi.org/10.1590/s2175-97902023e22452