Asparaginase-induced acute pancreatitis in children: unveiling predictive biomarkers for precision care
DOI:
https://doi.org/10.1590/s2175-97902025e24121Keywords:
Asparaginase, Acute lymphoblastic leukemia, Pancreatitis, Genetic factorsAbstract
Asparaginase (ASN) is a crucial drug in the treatment of acute lymphoblastic leukemia (ALL). However, it is associated with an important and unique toxicity profile compared to other types of chemotherapy. One of the most relevant toxicities is acute pancreatitis. Although it is frequently a reversible process, its severity may contraindicate the continued use of ASN, delay the entire chemotherapy regimen, and impact overall survival. So far, the pathophysiological mechanism that gives rise to this complication is not well defined. At the same time, some risk factors are being studied, mainly pharmacogenetic markers. This review will outline what is currently known about the main genetic polymorphisms associated with the risk of acute pancreatitis related to the use of asparaginase.
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