Toxicological and pharmacological evaluation of Discaria americana Gillies & Hook (Rhamnaceae) in mice
DOI:
https://doi.org/10.1590/S1984-82502012000200011Keywords:
Discaria americana^i1^sphamacogn, Medicinal plants, Discaria americana^i1^stoxicological analy, Discaria americana^i1^sacute toxic, Discaria americana^i1^ssubacute toxic, Discaria americana^i1^sanxiolytic eff, Discaria americana^i1^santinociceptive effAbstract
Medicinal plants (e.g. Discaria americana) have been used by populations for centuries. However, popular use is not enough to validate these plants as safe and effective medicinal products. The present study sought to evaluate the acute and subacute toxicity as well as the anxiolytic and antinociceptive effects of D. americana root bark and aerial parts extracts in mice. In acute toxicity studies, mice were treated with single intraperitoneal doses of the aforementioned extracts. Subacute toxicity studies were performed by oral administration of the extracts over 14 days. Anxiolytic studies consisted of the elevated plus maze method, and antinociceptive studies were based on the hot plate test. The LD50 value for D. americana aerial parts extract was established at >;500 mg/kg, and for the root bark extract, 400 mg/kg. D. americana aerial parts extract produced anxiolytic (250 mg/kg) and antinociceptive effects (125, 200 and 250 mg/kg). Conversely, D. americana root bark extract showed neither anxiolytic nor antinociceptive effects in mice.Downloads
Download data is not yet available.
Downloads
Published
2012-06-01
Issue
Section
Articles
License
All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.
The on line journal has open and free access.
How to Cite
Toxicological and pharmacological evaluation of Discaria americana Gillies & Hook (Rhamnaceae) in mice. (2012). Brazilian Journal of Pharmaceutical Sciences, 48(2), 273-280. https://doi.org/10.1590/S1984-82502012000200011