Preparation and characterisation of Dextran-70 hydrogel for controlled release of praziquantel

Authors

  • Flávio dos Santos Campos Universidade Estadual Paulista; School of Pharmaceutical Sciences
  • Douglas Lopes Cassimiro Universidade Estadual Paulista; Institute of Chemistry
  • Marisa Spirandeli Crespi Universidade Estadual Paulista; Institute of Chemistry
  • Adélia Emília Almeida Universidade Estadual Paulista; School of Pharmaceutical Sciences
  • Maria Palmira Daflon Gremião Universidade Estadual Paulista; School of Pharmaceutical Sciences

DOI:

https://doi.org/10.1590/S1984-82502013000100009

Keywords:

Hydrogel^i1^sdevelopm, Hydrogel^i1^sbiopharmaceutical propert, Dextran^i1^shydrogel developm, Praziquantel^i1^scontrolled rele, Hydrogel^i1^sswelling t

Abstract

A hydrogel was developed from 70 kDa dextran (DEX-70) and praziquantel (PZQ) incorporated as a model drug. Biopharmaceutical properties, such as solubility and dissolution rate, were analysed in the design of the hydrogel. Furthermore, the hydrogel was also characterized by IR spectroscopy and DSC. Tests of the swelling rate showed that the hydrogel swelled slowly, albeit faster than the rate for the free polymer. In dissolution tests, the hydrogel released the drug slowly and continuously. This slow release was similar to that observed in the swelling tests and resulted in controlled release of the drug. Thus, this dextran is a suitable polymer for the development of hydrogels as vehicles for the controlled release of drugs.

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Published

2013-03-01

Issue

Vol. 49 No. 1 (2013)

Section

Articles

License

All content of the journal, except where identified, is licensed under a Creative Commons attribution-type BY.

The on line journal has open and free access.

How to Cite

Preparation and characterisation of Dextran-70 hydrogel for controlled release of praziquantel . (2013). Brazilian Journal of Pharmaceutical Sciences, 49(1), 75-83. https://doi.org/10.1590/S1984-82502013000100009