Alginate wound dressing containing calendula extract: sterile and non-sterile properties evaluation
DOI:
https://doi.org/10.1590/s2175-97902025e24329Keywords:
Wound dressing, Biomaterial, Gamma irradiation, Sterilization, Pot marigoldAbstract
This study evaluated the effects of gamma sterilization on a novel wound dressing composed of polyester-viscose gauze impregnated with an alginate hydrogel containing 10% v/v calendula glycolic extract. The investigation examined the impact of 15 kGy gamma radiation on the morphology and properties of the alginate-calendula wound dressing, including swelling, biodegradation, water vapor permeability, and pH. The HPLC fingerprint of gamma-irradiated calendula glycolic extract was also analyzed. Physicochemical properties of sterile and non-sterile dressings were characterized using scanning electron microscopy (SEM-FEG), X-ray diffraction (XRD), and thermal analysis. Both the non-irradiated and irradiated calendula glycolic extracts had similar chromatographic fingerprint profiles. Hydrogel coverage on the gauze fabric was observed in SEM images, along with slight surface modifications in the sterile dressing. XRD and thermal analyses presented peaks associated with the textile substrate and reduced weight loss due to water evaporation caused by sterilization. After irradiation with gamma rays, swelling (500-600%), biodegradation (70-80%), water vapor permeability (70-85 g/m.day.Pa), and pH (6.4) of dressings did not show any significant changes. Overall, the findings show that gamma radiation maintains the flavonoid content, moisture level, low biodegradation rate, and slightly acidic pH, which makes it an appropriate method for sterilizing the alginate-calendula wound dressing.
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