The aqueous extract of Cissus verticillata leaves prevents diabetic allodynia in type 1 and type 2 diabetic mouse models regardless of glycemic control

Authors

  • Eslen Delanogare Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Roberto Bayestorff Heberle Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Wellinghton de Medeiros Barros Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Scheila Iria Kraus Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Sara Pereira Braga Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Adriano Emanuel Machado Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Lucas Antônio dos Santos Barbosa Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Gustavo Jorge dos Santos Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Maique Weber Biavatti Universidade Federal de Santa Catarina image/svg+xml , Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil
  • Larissa Gabriela Faqueti Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Layzon Antonio Lemos da Silva Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Louis P. Sandjo Departamento de Ciências Farmacêuticas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml
  • Eduardo Luiz Gasnhar Moreira Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Departamento de Ciências Fisiológicas, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil , Universidade Federal de Santa Catarina image/svg+xml

DOI:

https://doi.org/10.1590/s2175-97902025e24621

Keywords:

Aqueous extract, Cissus verticillata, Diabetes, Allodynia, Pain

Abstract

Cissus verticillata (L.) Nicolson & C.E. Jarvis, popularly known as “plant-insulin,” is used in Brazilian popular medicine for various conditions, including diabetes. Despite its usage, scientific research on its effects remains limited. In this regard, this study aimed to explore the potential anti-diabetic effects of C. verticillata’s aqueous extract (AECv) in mouse models of type 1 diabetes (T1D) and type 2 diabetes (T2D). T1D was induced in Swiss mice via daily intraperitoneal administration of 50 mg/ kg streptozotocin (STZ) for five days. Mice were then treated orally with saline or AECv (30 mg/kg/ day or 300 mg/kg/day) for three weeks. After 18 days, behavioral tests were conducted, and glucose measurements were taken. To mimic T2D-like conditions, mice were fed standard rodent chow (SD) or a high-fat, high-fructose diet (western diet, WD) for 15 days and then received daily treatment with vehicle or AECv (300 mg/kg/day) for 21 days. Behavioral tests and a glucose tolerance test were then performed. AECv did not improve STZ- and WD-induced glucose impairments or anxiogenic like behavior but significantly alleviated mechanical allodynia in both models. While AECv lacked hypoglycemic, anxiolytic, or antidepressant effects, it demonstrated the potential to enhance the pain sensitivity threshold.

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Published

2025-11-10

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Vol. 61 (2025)

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How to Cite

The aqueous extract of Cissus verticillata leaves prevents diabetic allodynia in type 1 and type 2 diabetic mouse models regardless of glycemic control. (2025). Brazilian Journal of Pharmaceutical Sciences, 61, e24621. https://doi.org/10.1590/s2175-97902025e24621

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