Topical formulation with ascorbyl tetraisopalmitate and synthetic tripeptide, combined with facial muscle exercises

Andreza Sonego Furlan; Mariane Massufero Vergilio; Louise Idalgo Vasques; Maria Eduarda Eid Martins; Gislaine Ricci Leonardi

doi:10.1590/s2175-97902025e24350

Authors

Andreza Sonego Furlan Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil , State University of Campinas (UNICAMP)
Mariane Massufero Vergilio Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil , State University of Campinas (UNICAMP)
Louise Idalgo Vasques Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil , State University of Campinas (UNICAMP)
Maria Eduarda Eid Martins Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil , State University of Campinas (UNICAMP)
Gislaine Ricci Leonardi Faculdade de Ciências Farmacêuticas, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil , State University of Campinas (UNICAMP)

DOI:

https://doi.org/10.1590/s2175-97902025e24350

Keywords:

Ascorbic acid, Ascorbyl tetraisopalmitate, Instrumental methods, Skin aging, Synthetic tripeptide, Facial muscle exercises

Abstract

Facial aging involves natural processes such as bone resorption, subcutaneous volume loss, ligament laxity, and skin flaccidity. Currently, many aesthetic treatments are used to attenuate or delay the signs of facial aging, including facial exercises. They intend to improve skin elasticity, muscle tone, collagen production, and add (or reduce) volume of specific regions of the face. This study evaluated the effectiveness of a cosmetic formulation with ascorbyl tetraisopalmitate and synthetic tripeptide, combined with facial muscle exercises, in 43 healthy women aged between 30 and 65 years old. Participants were randomized into 3 groups: cosmetic formulation, cosmetic formulation + facial exercises, and facial exercises only. Instrumental measurements and self-assessment questionnaires were used to evaluate skin parameters. Significant improvement in skin firmness and elasticity were observed and attributed to the use of the cosmetic formulation. Additionally, participants noticed qualitative improvements in the appearance of their overall skin and wrinkles. High satisfaction scores were recorded for the facial exercise device and the formulation applied in the study. In conclusion, the cosmetic formulation had a positive impact on skin health, and the association of facial exercises, within time and conditions of this study, did not significantly increase the results caused by the formulation.

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References

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Topical formulation with ascorbyl tetraisopalmitate and synthetic tripeptide, combined with facial muscle exercises

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