Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer

Authors

  • Caio Sergio Rizkallah Nahas Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Sergio Carlos Nahas Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Ulysses Ribeiro-Junior Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Leonardo Bustamante-Lopez Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Carlos Frederico Sparapan Marques Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Rodrigo Ambar Pinto Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Antonio Rocco Imperiale Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Guilherme Cutait Cotti Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • William Carlos Nahas Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Urologia, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Daher Cezar Chade Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Urologia, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Dariane Sampaio Piato Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Ginecologia, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Fabio Busnardo Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Plastica, Instituto do Cancer do Estado de Sao Paulo (ICESP)
  • Ivan Cecconello Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Servico de Cirurgia Gastrointestinal, Instituto do Cancer do Estado de Sao Paulo (ICESP)

DOI:

https://doi.org/10.6061/clinics/2017(05)01

Keywords:

Colorectal Cancer, Survival, Recurrence

Abstract

OBJECTIVES: This study sought to determine the clinical and pathological factors associated with perioperative morbidity, mortality and oncological outcomes after multivisceral en bloc resection in patients with colorectal cancer. METHODS: Between January 2009 and February 2014, 105 patients with primary colorectal cancer selected for multivisceral resection were identified from a prospective database. Clinical and pathological factors, perioperative morbidity and mortality and outcomes were obtained from medical records. Estimated local recurrence and overall survival were compared using the log-rank method, and Cox regression analysis was used to determine the independence of the studied parameters. ClinicalTrials.gov: NCT02859155. RESULTS: The median age of the patients was 60 (range 23-86) years, 66.7% were female, 80% of tumors were located in the rectum, 11.4% had stage-IV disease, and 54.3% received neoadjuvant chemoradiotherapy. The organs most frequently resected were ovaries and annexes (37%). Additionally, 30.5% of patients received abdominoperineal resection. Invasion of other organs was confirmed histologically in 53.5% of patients, and R0 resection was obtained in 72% of patients. The overall morbidity rate of patients in this study was 37.1%. Ureter resection and intraoperative blood transfusion were independently associated with an increased number of complications. The 30-day postoperative mortality rate was 1.9%. After 27 (range 5-57) months of follow-up, the mortality and local recurrence rates were 23% and 15%, respectively. Positive margins were associated with a higher recurrence rate. Positive margins, lymph node involvement, stage III/IV disease, and stage IV disease alone were associated with lower overall survival rates. On multivariate analysis, the only factor associated with reduced survival was lymph node involvement. CONCLUSIONS: Multivisceral en bloc resection for primary colorectal cancer can be performed with acceptable rates of morbidity and mortality and may lead to favorable oncological outcomes.

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Published

2017-05-01

Issue

Section

Clinical Sciences

How to Cite

Nahas, C. S. R., Nahas, S. C., Ribeiro-Junior, U., Bustamante-Lopez, L., Marques, C. F. S., Pinto, R. A., Imperiale, A. R., Cotti, G. C., Nahas, W. C., Chade, D. C., Piato, D. S., Busnardo, F., & Cecconello, I. (2017). Prognostic factors affecting outcomes in multivisceral en bloc resection for colorectal cancer. Clinics, 72(5), 258-264. https://doi.org/10.6061/clinics/2017(05)01