Placental weight and birth weight to placental weight ratio in monochorionic and dichorionic growth-restricted and non-growth-restricted twins

Authors

  • Mariângela Alves Souza Universidade de São Paulo; Faculdade de Medicina; Departamento de Ginecologia e Obstetricia
  • Maria de Lourdes Brizot Universidade de São Paulo; Faculdade de Medicina; Departamento de Ginecologia e Obstetricia
  • Sckarlet Ernandes Biancolin Universidade de São Paulo; Faculdade de Medicina; Departamento de Ginecologia e Obstetricia
  • Regina Schultz Universidade de São Paulo; Hospital das Clinicas HCFMUSP, Faculdade de Medicina; Departamento de Patologia
  • Mário Henrique Burlacchini de Carvalho Universidade de São Paulo; Faculdade de Medicina; Departamento de Ginecologia e Obstetricia
  • Rossana Pulcineli Vieira Francisco Universidade de São Paulo; Faculdade de Medicina; Departamento de Ginecologia e Obstetricia
  • Marcelo Zugaib Universidade de São Paulo; Faculdade de Medicina; Departamento de Ginecologia e Obstetricia

DOI:

https://doi.org/10.6061/clinics/2017(05)02

Keywords:

Twin Pregnancy, Placental Pathology, Placental Weight, Birth Weight/Placental Weight Ratio, Monochorionic Twin, Growth Restriction

Abstract

OBJECTIVE: The aim of the present study was to compare the placental weight and birth weight/placental weight ratio for intrauterine growth-restricted and non-intrauterine growth-restricted monochorionic and dichorionic twins. METHODS: This was a retrospective analysis of placentas from twin pregnancies. Placental weight and the birth weight/placental weight ratio were compared in intrauterine growth-restricted and non-intrauterine growth-restricted monochorionic and dichorionic twins. The association between cord insertion type and placental lesions in intrauterine growth-restricted and non-intrauterine growth-restricted monochorionic and dichorionic twins was also investigated. RESULTS: A total of 105 monochorionic (intrauterine growth restriction=40; non-intrauterine growth restriction=65) and 219 dichorionic (intrauterine growth restriction=57; non-intrauterine growth restriction=162) placentas were analyzed. A significantly lower placental weight was observed in intrauterine growth-restricted monochorionic (p=0.022) and dichorionic (p<0.001) twins compared to non-intrauterine growth-restricted twins. There was no difference in the birth weight/placental weight ratio between the intrauterine growth restriction and non-intrauterine growth restriction groups for either monochorionic (p=0.36) or dichorionic (p=0.68) twins. Placental weight and the birth weight/placental weight ratio were not associated with cord insertion type or with placental lesions. CONCLUSION: Low placental weight, and consequently reduced functional mass, appears to be involved in fetal growth restriction in monochorionic and dichorionic twins. The mechanism by which low placental weight influences the birth weight/placental weight ratio in intrauterine growth-restricted monochorionic and dichorionic twins needs to be determined in larger prospective studies.

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Published

2017-05-01

Issue

Section

Clinical Sciences

How to Cite

Souza, M. A., de Lourdes Brizot, M., Biancolin, S. E., Schultz, R., de Carvalho, M. H. B., Francisco, R. P. V., & Zugaib, M. (2017). Placental weight and birth weight to placental weight ratio in monochorionic and dichorionic growth-restricted and non-growth-restricted twins. Clinics, 72(5), 265-271. https://doi.org/10.6061/clinics/2017(05)02