Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury

Authors

  • Hermes Vieira Barbeiro Universidade de São Paulo; Faculdade de Medicina FMUSP; Departamento de Emergencias Clinicas
  • Marcel Autran César Machado Hospital Sírio-Libanês
  • Heraldo Possolo de Souza Universidade de São Paulo; Faculdade de Medicina FMUSP; Departamento de Emergencias Clinicas
  • Fabiano Pinheiro da Silva Universidade de São Paulo; Faculdade de Medicina FMUSP; Departamento de Emergencias Clinicas
  • Marcel Cerqueira César Machado Hospital Sírio-Libanês

DOI:

https://doi.org/10.6061/clinics/2017(10)10

Keywords:

Liver, Inflammation, Intestinal Barrier, Bacterial Translocation, IGFBP-1

Abstract

OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage. METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection. RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed. CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations.

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Published

2017-10-01

Issue

Vol. 72 No. 10 (2017)

Section

Rapid Communication

How to Cite

Barbeiro, H. V., Machado, M. A. C., de Souza, H. P., da Silva, F. P., & Machado, M. C. C. (2017). Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury. Clinics, 72(10), 645-648. https://doi.org/10.6061/clinics/2017(10)10